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Sacubitril/Valsartan

Name: Sacubitril/Valsartan
Brand: TargetMol
SKU: T2318
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2318Cas No. 936623-90-4

Alias Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Sacubitril/Valsartan

🥰Excellent

Purity: 99.91%

Catalog No. T2318Alias Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696Cas No. 936623-90-4

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$126	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$198	In Stock	In Stock
500 mg	$492	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
In vitro	LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio)[1].
Synonyms	Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696

Chemical Properties

Molecular Weight	957.99
Formula	C₄₈H₅₅N₆O₈Na₃.2.5H₂O
Cas No.	936623-90-4
Smiles	CC(C)[C@@H](C([O-])=O)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=N[N-]3)C=CC=C2.CCOC([C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC4=CC=C(C5=CC=CC=C5)C=C4)=O.[Na+].O.[Na+].[Na+].O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (9.82 mM), Heating is recommended.

H2O: 92 mg/mL (96.03 mM), Sonication is recommended.

DMSO: 45.45 mg/mL (47.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.0439 mL	5.2193 mL	10.4385 mL	52.1926 mL
5 mM	0.2088 mL	1.0439 mL	2.0877 mL	10.4385 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
10 mM	0.1044 mL	0.5219 mL	1.0439 mL	5.2193 mL
20 mM	0.0522 mL	0.2610 mL	0.5219 mL	2.6096 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0439 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc