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Sacubitril/Valsartan

Name: Sacubitril/Valsartan
Brand: TargetMol
SKU: T2318
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2318Cas No. 936623-90-4

Alias Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Sacubitril/Valsartan

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Purity: 99.91%

Catalog No. T2318Alias Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696Cas No. 936623-90-4

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	In Stock	In Stock
5 mg	$61	In Stock	In Stock
10 mg	$85	In Stock	In Stock
25 mg	$126	In Stock	In Stock
50 mg	$158	In Stock	In Stock
100 mg	$198	In Stock	In Stock
500 mg	$492	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
In vitro	LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio)[1].
Synonyms	Valsartan, Sacubitril mixture with Valsartan, Sacubitril, LCZ696

Chemical Properties

Molecular Weight	957.99
Formula	C₄₈H₅₅N₆O₈Na₃.2.5H₂O
Cas No.	936623-90-4
Smiles	CC(C)[C@@H](C([O-])=O)N(C(CCCC)=O)CC1=CC=C(C=C1)C2=C(C3=NN=N[N-]3)C=CC=C2.CCOC([C@H](C)C[C@H](NC(CCC([O-])=O)=O)CC4=CC=C(C5=CC=CC=C5)C=C4)=O.[Na+].O.[Na+].[Na+].O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (9.39 mM), Heating is recommended.

H2O: 92 mg/mL (96.03 mM), Sonication is recommended.

DMSO: 45.45 mg/mL (47.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.0439 mL	5.2193 mL	10.4385 mL	52.1926 mL
5 mM	0.2088 mL	1.0439 mL	2.0877 mL	10.4385 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
10 mM	0.1044 mL	0.5219 mL	1.0439 mL	5.2193 mL
20 mM	0.0522 mL	0.2610 mL	0.5219 mL	2.6096 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0439 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc