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RS-246204

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Catalog No. T16799Cas No. 878451-87-7
Alias RS246204, RS 246204

RS-246204 is an R-spondin-1 substitute compound capable of initiating and sustaining intestinal organoids in R-spondin-1-deficient media, activating R-spondin-dependent pathways in DSS-induced colitis models, and promoting regeneration of damaged intestinal epithelium.

RS-246204

RS-246204

😃Good
Catalog No. T16799Alias RS246204, RS 246204Cas No. 878451-87-7
RS-246204 is an R-spondin-1 substitute compound capable of initiating and sustaining intestinal organoids in R-spondin-1-deficient media, activating R-spondin-dependent pathways in DSS-induced colitis models, and promoting regeneration of damaged intestinal epithelium.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,1106-8 weeks6-8 weeks
50 mg$1,4506-8 weeks6-8 weeks
100 mg$2,2806-8 weeks6-8 weeks
1 mL x 10 mM (in DMSO)$3656-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
RS-246204 is an R-spondin-1 substitute compound capable of initiating and sustaining intestinal organoids in R-spondin-1-deficient media, activating R-spondin-dependent pathways in DSS-induced colitis models, and promoting regeneration of damaged intestinal epithelium.
In vitro
High concentrations of R-spondin-1 protein can substitute for R-spondin-1 in initiating and maintaining organoids, exhibiting differentiation and self-renewal capabilities comparable to those of intestinal organoids cultured with added R-spondin-1. Intestinal organoids derived from RS-246204 successfully produce carboxypeptidase-induced swelling and establish an organoid-based epithelial-mesenchymal transition model [1].
In vivo
RS-246204 increased BrdU+ cell numbers and body weight in a DSS-induced colitis model, activated the R-spondin-dependent pathway in Lgr5 stem cells, promoted intestinal epithelial regeneration, and alleviated disease severity [1].
SynonymsRS246204, RS 246204
Chemical Properties
Molecular Weight339.37
FormulaC16H13N5O2S
Cas No.878451-87-7
SmilesO=C1NC(=O)N(C=2N=C(SC=3N=C4C=CC=CC4=CC3)N(C12)C)C
Relative Density.1.54 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL (insoluble), Sonication is recommended.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

RS-246204
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