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Anti-Endo G Antibody (1O411)
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Catalog No. TMAC-01291
Alias NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG
Anti-Endo G Antibody (1O411) is a Rabbit antibody targeting Endo G. Anti-Endo G Antibody (1O411) can be used in WB,ICC.
Anti-Endo G Antibody (1O411)
Anti-Endo G Antibody (1O411)
😃Good
Catalog No. TMAC-01291Alias NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG
Anti-Endo G Antibody (1O411) is a Rabbit antibody targeting Endo G. Anti-Endo G Antibody (1O411) can be used in WB,ICC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Endo G Antibody (1O411) is a Rabbit antibody targeting Endo G. Anti-Endo G Antibody (1O411) can be used in WB,ICC. |
| Synonyms | NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG |
| Ig Type | IgG |
| Clone | 1O411 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Endo G on mouse heart tissue lysate using anti-Endo G antibody at 1/500 dilution. 2. ICC staining Endo G in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining Endo G in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Endo G in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised. |
| Application | |
| Recommended Dose | WB: 1:500-1000; ICC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Endonuclease G (ENDOG), a nuclear encoded protein, localizes to the mitochondria. This sugar-nonspecific nuclease, responsible for major mitochondrial nuclease activity, preferentially cleaves single-stranded DNA(ssDNA). Synthesized as a propeptide with an amino-terminal presequence that targets the nuclease to mitochondria, ENDOG translocates to neuclei on apoptotic stimulation and act as a nuclease without sequence specificity. Both exonucleases and DNase I stimulate the ability of ENDOG to generate double-stranded DNA cleavage products at physiological ionic strengths, suggesting that these activities work in concert with ENDOG in apoptotic cells to ensure efficient DNA breakdown. In addition to deoxyribonuclease activities, ENDOG also has ribonuclease (RNase) and RNase H activities. ENDOG is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. ENDOG exists in the mitochondrial intermembrane space, but not in the matrix where mtDNA replication occurs. This enzyme provides an important nicking function for mitochondrial DNA specifically cleaving DNA at GC tracts. Human ENDOG maps to chromosome 9q34.11. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 36 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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