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STAT3-IN-3
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Catalog No. T13010 Copy Product Info
Purity: 99.49%
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STAT3-IN-3 is a potent and highly selective targeted STAT3 inhibitor with significant anti-proliferative activity. It effectively induces apoptosis in breast cancer cells. As a mitochondrially targeted STAT3 inhibitor with great research potential, it has good application value in tumor mechanism exploration and anti-cancer research.
Cas No. 2361304-26-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $123 | - | In Stock | |
| 5 mg | $296 | - | In Stock | |
| 10 mg | $478 | - | In Stock | |
| 25 mg | $957 | - | In Stock | |
| 50 mg | $1,430 | - | In Stock | |
| 100 mg | $2,280 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.49%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STAT3-IN-3 is a potent and highly selective targeted STAT3 inhibitor with significant anti-proliferative activity. It effectively induces apoptosis in breast cancer cells. As a mitochondrially targeted STAT3 inhibitor with great research potential, it has good application value in tumor mechanism exploration and anti-cancer research. |
| In vitro | Methods: In vitro cell experiments and molecular biology assays were used to evaluate the effects of STAT3-IN-3 on the phosphorylation levels of STAT3 and its upstream and downstream related kinases, tumor cell proliferation, target gene expression, and STAT3 DNA-binding ability. Meanwhile, the levels of reactive oxygen species (ROS), mitochondrial membrane potential, and cleavage levels of apoptosis-related proteins were detected to clarify its pro-apoptotic mechanism. Results: 1.STAT3-IN-3 did not alter the phosphorylation levels of STAT1, JAK2, Src, and Erk1/2, indicating a certain degree of target specificity in its action. 2.STAT3-IN-3 significantly inhibited the proliferation of various tumor cells, with IC₅₀ values of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM for MDA‑MB‑231, HCT‑116, HepG2, and MCF‑7 cells, respectively. 3.STAT3-IN-3 effectively inhibited the tyrosine and serine phosphorylation of STAT3, reduced the DNA-binding activity of STAT3, and downregulated the expression of downstream target genes Bcl-2 and Cyclin D1. 4.Treatment of cells with 1–4 μM STAT3-IN-3 for 24 hours increased intracellular ROS production, decreased mitochondrial membrane potential, thereby activating the mitochondrial apoptotic pathway. Meanwhile, it promoted the cleavage of caspase-9, caspase-3, and PARP proteins, initiating the cellular apoptotic program [1]. |
| In vivo | Methods: A 4T1 breast cancer xenograft animal model was used. STAT3-IN-3 was administered via daily intraperitoneal injection at a dose of 10 mg/kg to 20 mg/kg for 14 consecutive days, and its in vivo antitumor effect was observed and evaluated. Results: STAT3-IN-3 (10–20 mg/kg, intraperitoneal injection once daily for 14 consecutive days) significantly inhibited the growth of 4T1 breast cancer xenografts in vivo, showing good in vivo antitumor activity [1]. |
| Molecular Weight | 600.48 |
| Formula | C27H26BrN3O6S |
| Cas No. | 2361304-26-7 |
| Smiles | O=C1OC=2C=C(C=CC2C=C1C(=O)N3CCN(C(=O)C4=CC=5C(Br)=CC=CC5S4(=O)=O)CC3)N(CC)CC |
| Relative Density. | 1.572 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (6.66 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: STAT3-IN-3 chemical structure | STAT3-IN-3 in vivo | STAT3-IN-3 in vitro | STAT3-IN-3 formula | STAT3-IN-3 molecular weight
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