Shopping Cart

Remove All
Your shopping cart is currently empty

DB04760

Name: DB04760
Brand: TargetMol
SKU: T15055
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15055Cas No. 544678-85-5

Alias MMP-13 Inhibitor

DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.

DB04760

🥰Excellent

Purity: 99.79%

Catalog No. T15055Alias MMP-13 InhibitorCas No. 544678-85-5

DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$228	In Stock
10 mg	$343	In Stock
25 mg	$579	In Stock
50 mg	$829	In Stock
100 mg	$1,150	In Stock
500 mg	$2,280	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.
Targets&IC50	MMP13:8 nM
Synonyms	MMP-13 Inhibitor

Chemical Properties

Molecular Weight	410.42
Formula	C₂₂H₂₀F₂N₄O₂
Cas No.	544678-85-5
Smiles	Cc1cc(CNC(=O)c2cc(ncn2)C(=O)NCc2ccc(F)c(C)c2)ccc1F
Relative Density.	1.286 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (219.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4365 mL	12.1826 mL	24.3653 mL	121.8264 mL
5 mM	0.4873 mL	2.4365 mL	4.8731 mL	24.3653 mL
10 mM	0.2437 mL	1.2183 mL	2.4365 mL	12.1826 mL
20 mM	0.1218 mL	0.6091 mL	1.2183 mL	6.0913 mL
50 mM	0.0487 mL	0.2437 mL	0.4873 mL	2.4365 mL
100 mM	0.0244 mL	0.1218 mL	0.2437 mL	1.2183 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc