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SMARCA2-IN-10

Name: SMARCA2-IN-10
Brand: TargetMol
SKU: T210456
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T210456Cas No. 82131-85-9

SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM) that induces death in SMARCA4-deficient tumor cells. It can be used to study SMARCA4-mutant non-small cell lung cancer, small cell ovarian cancer, and melanoma.

SMARCA2-IN-10

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Catalog No. T210456Cas No. 82131-85-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
5 mg	$79	-	In Stock
10 mg	$128	-	In Stock
25 mg	$258	-	In Stock
50 mg	$413	-	In Stock
100 mg	$589	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM) that induces death in SMARCA4-deficient tumor cells. It can be used to study SMARCA4-mutant non-small cell lung cancer, small cell ovarian cancer, and melanoma.
Targets&IC50	SMARCA2:17.68 μM

Chemical Properties

Molecular Weight	496.47
Formula	C₂₈H₂₀N₂O₇
Cas No.	82131-85-9
Smiles	O=C(O)C=1C=CC=CC1C(=O)NC2=CC=C(OC3=CC=C(C=C3)NC(=O)C=4C=CC=CC4C(=O)O)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (100.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0142 mL	10.0711 mL	20.1422 mL	100.7110 mL
5 mM	0.4028 mL	2.0142 mL	4.0284 mL	20.1422 mL
10 mM	0.2014 mL	1.0071 mL	2.0142 mL	10.0711 mL
20 mM	0.1007 mL	0.5036 mL	1.0071 mL	5.0356 mL
50 mM	0.0403 mL	0.2014 mL	0.4028 mL	2.0142 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	1.0071 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc