HER3/ERBB3 Protein, Human, Recombinant (mFc)

Name: HER3/ERBB3 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-03761
Rating: 4.5 (1 reviews)

(Synonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3) Copy Product Info

Synonyms: p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3

Catalog No. TMPY-03761 Copy Product Info

HER3/ERBB3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95 kDa and the accession number is P21860.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$359	7-10 days	7-10 days
100 µg	$696	7-10 days	7-10 days
200 µg	$1,060	7-10 days	7-10 days
500 µg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Loaded Human NRG1 Beta (245AA) on APS Biosensor, can bind Human HER3-mFc with an affinity constant of 3.6 nM as determined in BLI assay. Loaded Human NRG1Beta (246AA) on APS Biosensor, can bind Human HER3-mFc with an affinity constant of 4.3 nM as determined in BLI assay.
Description	HER3/ERBB3 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 95 kDa and the accession number is P21860.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	P21860
Construction	Ser20-Thr643
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	p85-sErbB3, p45-sErbB3, p180-ErbB3, MDA-BF-1, LCCS2, HER3, erbB3-S, ErbB-3, erb-b2 receptor tyrosine kinase 3, EEBB3, c-erbB-3, c-erbB3
Research Background	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

95 kDa (predicted); 120-135 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.