BMP-4 Protein, Mouse, Recombinant (rFc)

Name: BMP-4 Protein, Mouse, Recombinant (rFc)
Brand: TargetMol
SKU: TMPY-00431
Rating: 4.5 (1 reviews)

(Synonyms: bone morphogenetic protein 4, Bmp-4, Bmp2b-1, Bmp2b1, Bmp2b) Copy Product Info

Synonyms: bone morphogenetic protein 4, Bmp-4, Bmp2b-1, Bmp2b1, Bmp2b

Catalog No. TMPY-00431 Copy Product Info

BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.

Pack Size	Price	USA Stock	Global Stock
5 µg	$119	7-10 days	7-10 days
10 µg	$196	-	In Stock
20 µg	$293	7-10 days	7-10 days
50 µg	$497	7-10 days	7-10 days
100 µg	$773	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:> 92 % as determined by SDS-PAGE.

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.
Species	Mouse
Expression System	HEK293 Cells
Tag	N-rFc
Accession Number	P21275
Construction	A DNA sequence encoding the mouse BMP4 (NP_031580.2) (Ser293-Arg408) was expressed with the Fc region of rabbit IgG at the N-terminus.. Predicted N terminal: Ser
Protein Purity	> 92 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.15 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	bone morphogenetic protein 4, Bmp-4, Bmp2b-1, Bmp2b1, Bmp2b
Research Background	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.

Chemical Properties

Molecular Weight

40.6 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.