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VBY-825

Name: VBY-825
Brand: TargetMol
SKU: T13288
Price: 278 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13288Cas No. 1310340-58-9

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

VBY-825

🥰Excellent

Purity: 99.91%

Catalog No. T13288Cas No. 1310340-58-9

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

Pack Size	Price	Availability
1 mg	$278	In Stock
2 mg	$413	In Stock
5 mg	$689	In Stock
10 mg	$979	In Stock
25 mg	$1,460	In Stock
50 mg	$1,960	In Stock
100 mg	$2,650	In Stock

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Batch Information

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Purity:99.91%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

In vitro

VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

Chemical Properties

Molecular Weight	535.55
Formula	C₂₃H₂₉F₄N₃O₅S
Cas No.	1310340-58-9
Smiles	[C@@H](N[C@H](C(N[C@H](C(C(NC1CC1)=O)=O)CC)=O)CS(CC2CC2)(=O)=O)([C@](F)(F)F)C3=CC=C(F)C=C3
Relative Density.	1.39 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (233.40 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8672 mL	9.3362 mL	18.6724 mL	93.3620 mL
5 mM	0.3734 mL	1.8672 mL	3.7345 mL	18.6724 mL
10 mM	0.1867 mL	0.9336 mL	1.8672 mL	9.3362 mL
20 mM	0.0934 mL	0.4668 mL	0.9336 mL	4.6681 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8672 mL
100 mM	0.0187 mL	0.0934 mL	0.1867 mL	0.9336 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc