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VBY-825

Name: VBY-825
Brand: TargetMol
SKU: T13288
Price: 278 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13288Cas No. 1310340-58-9

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

VBY-825

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Purity: 99.91%

Catalog No. T13288Cas No. 1310340-58-9

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$278	In Stock	In Stock
2 mg	$413	In Stock	In Stock
5 mg	$689	In Stock	In Stock
10 mg	$979	In Stock	In Stock
25 mg	$1,460	In Stock	In Stock
50 mg	$1,960	In Stock	In Stock
100 mg	$2,650	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

In vitro

VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.

Chemical Properties

Molecular Weight	535.55
Formula	C₂₃H₂₉F₄N₃O₅S
Cas No.	1310340-58-9
Smiles	[C@@H](N[C@H](C(N[C@H](C(C(NC1CC1)=O)=O)CC)=O)CS(CC2CC2)(=O)=O)([C@](F)(F)F)C3=CC=C(F)C=C3
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (233.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8672 mL	9.3362 mL	18.6724 mL	93.3620 mL
5 mM	0.3734 mL	1.8672 mL	3.7345 mL	18.6724 mL
10 mM	0.1867 mL	0.9336 mL	1.8672 mL	9.3362 mL
20 mM	0.0934 mL	0.4668 mL	0.9336 mL	4.6681 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8672 mL
100 mM	0.0187 mL	0.0934 mL	0.1867 mL	0.9336 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc