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VBY-825

🥰Excellent
Catalog No. T13288Cas No. 1310340-58-9

VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.

VBY-825

VBY-825

🥰Excellent
Purity: 99.91%
Catalog No. T13288Cas No. 1310340-58-9
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$278In StockIn Stock
2 mg$413In StockIn Stock
5 mg$689In StockIn Stock
10 mg$979In StockIn Stock
25 mg$1,460In StockIn Stock
50 mg$1,960In StockIn Stock
100 mg$2,650-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.91%
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Product Introduction

Bioactivity
Description
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
In vitro
VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.
Chemical Properties
Molecular Weight535.55
FormulaC23H29F4N3O5S
Cas No.1310340-58-9
Smiles[C@@H](N[C@H](C(N[C@H](C(C(NC1CC1)=O)=O)CC)=O)CS(CC2CC2)(=O)=O)([C@](F)(F)F)C3=CC=C(F)C=C3
Relative Density.1.39 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (233.40 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.47 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8672 mL9.3362 mL18.6724 mL93.3620 mL
5 mM0.3734 mL1.8672 mL3.7345 mL18.6724 mL
10 mM0.1867 mL0.9336 mL1.8672 mL9.3362 mL
20 mM0.0934 mL0.4668 mL0.9336 mL4.6681 mL
50 mM0.0373 mL0.1867 mL0.3734 mL1.8672 mL
100 mM0.0187 mL0.0934 mL0.1867 mL0.9336 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VBY-825VBY825VBY 825InhibitorinhibitCysteineProteaseCysteine ProteaseCathepsin
Related Tags: buy VBY-825 | purchase VBY-825 | VBY-825 cost | order VBY-825 | VBY-825 chemical structure | VBY-825 in vitro | VBY-825 formula | VBY-825 molecular weight
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