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Dixyrazine

Name: Dixyrazine
Brand: TargetMol
SKU: T19286
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19286Cas No. 2470-73-7

Alias UCB 3412

Dixyrazine (UCB 3412)has a transient antihypertensive effect, prevents cerebral edema induced by injections of ichthyosperm sulfate, and may be used in the study of neurologically related disorders.

Dixyrazine

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Purity: 99.19%

Catalog No. T19286Alias UCB 3412Cas No. 2470-73-7

Dixyrazine (UCB 3412)has a transient antihypertensive effect, prevents cerebral edema induced by injections of ichthyosperm sulfate, and may be used in the study of neurologically related disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
5 mg	$156	-	In Stock
10 mg	$259	-	In Stock
25 mg	$546	-	In Stock
1 mL x 10 mM (in DMSO)	$186	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.19%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Dixyrazine (UCB 3412)has a transient antihypertensive effect, prevents cerebral edema induced by injections of ichthyosperm sulfate, and may be used in the study of neurologically related disorders.
In vivo	Pretreatment with Dixyrazine (10 mg/kg) completely prevents brain edema and significantly reduces the increase of albumin in cerebrospinal fluid (CSF)[2]. In conscious rats subjected to acute hypertension provoked by i.v. adrenaline or bicuculline, the phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of 126I labeled serum albumin. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, at a dose of 5 mg/kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). The maximum mean arterial pressure (MAP) is slightly but not significantly lower in Dixyrazine-treated rats[1].
Synonyms	UCB 3412

Chemical Properties

Molecular Weight	427.6
Formula	C₂₄H₃₃N₃O₂S
Cas No.	2470-73-7
Smiles	CC(CN1CCN(CCOCCO)CC1)CN1c2ccccc2Sc2ccccc12
Relative Density.	1.0745 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (187.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3386 mL	11.6932 mL	23.3863 mL	116.9317 mL
5 mM	0.4677 mL	2.3386 mL	4.6773 mL	23.3863 mL
10 mM	0.2339 mL	1.1693 mL	2.3386 mL	11.6932 mL
20 mM	0.1169 mL	0.5847 mL	1.1693 mL	5.8466 mL
50 mM	0.0468 mL	0.2339 mL	0.4677 mL	2.3386 mL
100 mM	0.0234 mL	0.1169 mL	0.2339 mL	1.1693 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Dixyrazine