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STAT6-IN-10

Name: STAT6-IN-10
Brand: TargetMol
SKU: T212845
Rating: 4.5 (1 reviews)

Catalog No. T212845 Copy Product Info

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STAT6-IN-10 is a highly active signal transducer and activator of transcription 6 (STAT6) inhibitor with an EC₅₀ of 0.002 μM. It inhibits the secretion of CCL17 in human peripheral whole blood with an IC₅₀ of 0.095 μM and can be used in research on skin diseases and respiratory disorders.

STAT6-IN-10

Copy Product Info

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Catalog No. T212845

Cas No. 3092076-19-9

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Product Introduction

Bioactivity

Description	STAT6-IN-10 is a highly active signal transducer and activator of transcription 6 (STAT6) inhibitor with an EC₅₀ of 0.002 μM. It inhibits the secretion of CCL17 in human peripheral whole blood with an IC₅₀ of 0.095 μM and can be used in research on skin diseases and respiratory disorders.
Targets&IC50	STAT6:2 nM (EC50), CCL17:95 nM

Chemical Properties

Molecular Weight	507.59
Formula	C₂₉H₂₉N₇O₂
Cas No.	3092076-19-9
Smiles	O=C(NCC1=CC=C(C=C1)NC(=O)N(C)C)C2=NN(C3=CC=C(C=C23)C4=CC=C(C=C4)C5=NC=CN5C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (39.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9701 mL	9.8505 mL	19.7009 mL	98.5047 mL
5 mM	0.3940 mL	1.9701 mL	3.9402 mL	19.7009 mL
10 mM	0.1970 mL	0.9850 mL	1.9701 mL	9.8505 mL
20 mM	0.0985 mL	0.4925 mL	0.9850 mL	4.9252 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

STAT6IN10