T22318 |
Taletrectinib
|
1505515-69-4
|
98%
|
|
DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectiv...
|
T21482 |
Uniconazole
|
83657-22-1
|
98%
|
|
Uniconazole is a plant growth regulator that inhibit cytochrome P450 707As (Ki=68 nM). CYP707As is a major ABA catabolic enzyme that catabolize Abscisic acid, ac...
|
T4071 |
Repotrectinib
|
1802220-02-5
|
98%
|
|
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
|
TMS1743 |
Salvigenin
|
19103-54-9
|
98%
|
|
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
|
T8399 |
Crizotinib hydrochloride
|
1415560-69-8
|
98%
|
|
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
|
T3678 |
Entrectinib
|
1108743-60-7
|
98%
|
|
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
|
T3455 |
Merestinib
|
1206799-15-6
|
98%
|
|
LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively b...
|
T1661 |
Crizotinib
|
877399-52-5
|
98%
|
|
Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.
|
T63313 |
Unecritinib
|
1418026-92-2
|
98%
|
|
Unecritinib (TQ-B3101) is a potent, orally active, highly potent, blood-brain barrier permeable and low toxic inhibitor of EGFR tyrosine kinase with antitumor ac...
|
T11254 |
F-1
|
2244775-31-1
|
98%
|
|
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppress...
|
T60220 |
ROS kinases-IN-1
|
370096-57-4
|
98%
|
|
ROS kinases-IN-1 is a ROS tyrosine kinase inhibitor with IC50 value of 1.22 μM. ROS kinases-IN-1 shows anti-tumor activity.
|
T3061 |
Lorlatinib
|
1454846-35-5
|
98%
|
|
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
|
T38995 |
Taletrectinib free base
|
1505514-27-1
|
98%
|
|
Taletrectinib free base is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant R...
|