Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Glucocorticoid Receptor

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.

Relacorilant
T167271496510-51-0
Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing’s syndrome treatment.
  • $113
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Finerenone
T213951050477-31-0
Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.
  • $31
In Stock
Size
QTY
TargetMol | Inhibitor Hot
AZD9567
T143861893415-00-3
AZD9567 is a potent and orally active and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 value of 3.8 nM.It has demonstrated excellent efficacy in the Streptococcus cell wall (SCW) reactivation model of joint inflammation.
  • $212
In Stock
Size
QTY
Dexamethasone
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Cort108297
T150001018679-79-2
Cort108297 is a selective glucocorticoid receptor modulator and a selective GR antagonist with no affinity for other steroid receptors. Cort108297 showed a high affinity for GRs (Ki: 0.45nM).
  • $289
In Stock
Size
QTY
Methylprednisolone succinate
T223672921-57-5
Methylprednisolone succinate (Methylprednisolone hemisuccinate) is a synthetic glucocorticoid and is widely used as an anti-inflammatory agent.
  • $38
In Stock
Size
QTY
Hydrocortisone
T161450-23-7
Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilization, and renal calcium excretion, as well as suppressing immune and inflammatory responses.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Glucagon (1-29), bovine, human, porcine hydrochloride
T15389L28270-04-4
Glucagon (1-29), bovine, human, porcine hydrochloride (Porcine glucagon hydrochloride) is a peptide hormone produced by pancreatic α-cells that activates HNF4α, increases HNF4α phosphorylation, and stimulates gluconeogenesis.
  • $79
In Stock
Size
QTY
Mifepristone
T110284371-65-3
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
  • $37
In Stock
Size
QTY
Amcinonide
T026151022-69-6
Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Miricorilant
T333931400902-13-7In house
Miricorilant (CORT 118335) is a selective glucocorticoid receptor modulator for the study of digestive and metabolic disorders.
  • $293
In Stock
Size
QTY
6α-Methylprednisolone 21-hemisuccinate sodium salt
T02942375-03-3
6α-Methylprednisolone 21-hemisuccinate sodium salt (Asmacortone), a water-soluble ester, is used for allergic, cardiac, and hypoxic emergencies.
  • $39
In Stock
Size
QTY
Fluticasone furoate
T21404397864-44-7
Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.
  • $30
In Stock
Size
QTY
Prednisone acetate
T8396125-10-0
Prednisone acetate (Prednisone 21-acetate) is a glucocorticoid receptor agonist with immunomodulating properties and anti-inflammatory.
  • $41
In Stock
Size
QTY
Vamorolone
T1721713209-41-1
Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition and substantially decreases hormonal effects.
  • $31
In Stock
Size
QTY
TPI-1
T396279756-69-7
TPI-1 is a SHP-1 inhibitor.
  • $48
In Stock
Size
QTY
Drospirenone
T154167392-87-4
Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
  • $43
In Stock
Size
QTY
Spironolactone
T047652-01-7
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
  • $33
In Stock
Size
QTY
TargetMol | Citations Cited
Prednisolone
T156050-24-8
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
  • $29
In Stock
Size
QTY
Medrysone
T09772668-66-8
Medrysone (6α-Methyl-11β-hydroxyprogesterone) is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions is accomplished.
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
Diflorasone
T25482557-49-5
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm
  • $36
In Stock
Size
QTY
Hydrocortisone hemisuccinate
T46022203-97-6
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.
  • $30
In Stock
Size
QTY
Dexamethasone Phosphate disodium
T0947L2392-39-4
Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Halcinonide
T01073093-35-4
Halcinonide (Halciderm), a high-efficiency corticosteroid, is served as an anti-inflammatory agent used in topical preparations.
  • $40
In Stock
Size
QTY
Medroxyprogesterone Acetate
T126171-58-9
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Fluticasone (propionate)
T018880474-14-2
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.
  • $45
In Stock
Size
QTY
Nimodipine
T034366085-59-4
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
  • $40
In Stock
Size
QTY
TargetMol | Citations Cited
Ciclesonide
T2526126544-47-6
Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
  • $44
In Stock
Size
QTY
Glucocorticoid receptor agonist-1
T379082166375-82-0In house
Glucocorticoid receptor agonist-1, a potent glucocorticoid receptor agonist, has an IC50 of 2.8 nM[1].
  • $226
In Stock
Size
QTY
Eplerenone
T0083107724-20-9
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase levels, but has yet to be linked to cases of clinically apparent drug induced liver disease.
  • $44
In Stock
Size
QTY
Flumethasone
T11242135-17-3
Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
(20S)-Protopanaxatriol
T281034080-08-5
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
  • $53
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Cortisone
T288453-06-5
Cortisone (17-Hydroxy-11-dehydrocorticosterone) is a corticosteroid with potent glucocorticoid activity.
  • $39
In Stock
Size
QTY
Clobetasol propionate
T156125122-46-7
Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.
  • $32
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Cortodoxone
T2748152-58-9
Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Canrenone
T0354976-71-6
Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.
  • $30
In Stock
Size
QTY
Esaxerenone
T152461632006-28-0
Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
  • $64
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Megestrol acetate
T1284595-33-5
Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.
  • $45
In Stock
Size
QTY
Deoxycorticosterone acetate
T303356-47-3
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
  • $36
In Stock
Size
QTY
Hydrocortisone acetate
T124350-03-3
Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
  • $47
In Stock
Size
QTY
Triamcinolone acetonide
T082076-25-5
Triamcinolone acetonide (Azmacort) is a Corticosteroid. The mechanism of action of triamcinolone acetonide is as a Corticosteroid Hormone Receptor Agonist. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
  • $29
In Stock
Size
QTY
TargetMol | Citations Cited
Mometasone furoate
T153183919-23-7
Mometasone furoate (Sch32088) is a pregnadienediol derivative with anti-allergic and anti-inflammatory properties, used in the management of asthma and allergic rhinitis, as well as a topical treatment for skin disorders.
  • $39
In Stock
Size
QTY
Velsecorat
TQ02251196509-60-0
Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
  • $54
In Stock
Size
QTY
Fluorometholone
T3316426-13-1
Fluorometholone (Fluoromethalone) is a corticosteroid, most often used after laser-based refractive surgery. It is marketed under the brand names FML (Allergan) and Flarex (Alcon). Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
  • $40
In Stock
Size
QTY
AL 082D06
T1749256925-03-8
AL 082D06 (D-06), a selective nonsteroidal glucocorticoid receptor (GR) antagonist (Ki: 210 nM), exhibits outstanding selectivity against AR, ER, MR and PR(Ki > 10 uM).
  • $43
In Stock
Size
QTY
Budesonide
T009451333-22-3
Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects against multiple cells types and mediators referred to allergic and nonallergic-mediated inflammatory. What's more, the anti-inflammatory action of budesonide has been revealed to contribute to the effectiveness of asthma.
    Inquiry
    Dexamethasone acetate
    T09471177-87-3
    Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.
    • $45
    In Stock
    Size
    QTY
    Beclometasone dipropionate
    T11275534-09-8
    Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.
    • $40
    In Stock
    Size
    QTY