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MD-222

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Catalog No. T37041Cas No. 2136246-72-3

MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].

MD-222

MD-222

😃Good
Catalog No. T37041Cas No. 2136246-72-3
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$789InquiryInquiry
10 mg$1,360InquiryInquiry
25 mg$2,860InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].
In vitro
MD-222 (1-30 nM; 1-2 hours) treatment effectively reduces MDM2 protein levels and increases p53 levels in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells[1]. MD-222 (30-100 nM; 6 hours) increases the expression of p53-targeted genes, including MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong p53 activation[2]. MD-222 (4 days) inhibits cell growth in RS4;11 cells with an IC50 of 5.5 nM, but shows no effect on RS4;11/IRMI-2, MDA-MB-231, and MDA-MB-468 cells[1].
Chemical Properties
Molecular Weight893.84
FormulaC48H47Cl2FN6O6
Cas No.2136246-72-3
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (223.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 5 mg/mL (5.59 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1188 mL5.5938 mL11.1877 mL55.9384 mL
5 mM0.2238 mL1.1188 mL2.2375 mL11.1877 mL
10 mM0.1119 mL0.5594 mL1.1188 mL5.5938 mL
20 mM0.0559 mL0.2797 mL0.5594 mL2.7969 mL
50 mM0.0224 mL0.1119 mL0.2238 mL1.1188 mL
100 mM0.0112 mL0.0559 mL0.1119 mL0.5594 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MD-222MD222MD 222
Related Tags: buy MD-222 | purchase MD-222 | MD-222 cost | order MD-222 | MD-222 chemical structure | MD-222 in vitro | MD-222 formula | MD-222 molecular weight
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