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Azamulin

Name: Azamulin
Brand: TargetMol
SKU: T37183
Rating: 4.5 (1 reviews)

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Catalog No. T37183Cas No. 76530-44-4

Alias Antibiotic TDM 85-530

Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]

Azamulin

😃Good

Catalog No. T37183Alias Antibiotic TDM 85-530Cas No. 76530-44-4

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	6-8 weeks

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	Azamulin is a selective, irreversible inhibitor of cytochrome P450 (CYP) 3A isoforms (IC50 values range from 26 to 240 nM for CYP3A4 and CYP3A4/5 from different sources). [1] It is at least 50-fold less potent against CYP2J2 and 100-fold less effective against all other CYP isoforms. [1] Azamulin potently blocks the hydroxylation of testosterone and midazolam by CYP3A4.[2]
Targets&IC50	CYP3A:0.03-0.24 μM
Alias	Antibiotic TDM 85-530

Chemical Properties

Molecular Weight	478.65
Formula	C₂₄H₃₈N₄O₄S
Cas No.	76530-44-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (41.78 mM), Sonication is recommended.

DMF: 20 mg/mL (41.78 mM), Sonication is recommended.

Ethanol: 20 mg/mL (41.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0892 mL	10.4460 mL	20.8921 mL	104.4605 mL
5 mM	0.4178 mL	2.0892 mL	4.1784 mL	20.8921 mL
10 mM	0.2089 mL	1.0446 mL	2.0892 mL	10.4460 mL
20 mM	0.1045 mL	0.5223 mL	1.0446 mL	5.2230 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Azamulin