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Sodium Nitrite
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Catalog No. T77798Cas No. 7632-00-0
Alias Nitrous acid, sodium salt
Sodium Nitrite (Nitrous acid, sodium salt) is a compound that is not easy to store and will oxidize to nitric acid if left in the air.Sodium Nitrite has a variety of functions, both oxidizing and reducing, and is very versatile.
Sodium Nitrite
Copy Product Info🥰Excellent
Catalog No. T77798Alias Nitrous acid, sodium saltCas No. 7632-00-0
Sodium Nitrite (Nitrous acid, sodium salt) is a compound that is not easy to store and will oxidize to nitric acid if left in the air.Sodium Nitrite has a variety of functions, both oxidizing and reducing, and is very versatile.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $44 | In Stock | In Stock | |
| 50 mg | $61 | In Stock | In Stock | |
| 100 mg | $86 | In Stock | In Stock | |
| 500 mg | $198 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:White
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Product Introduction
Sodium Nitrite AI Summary
Sodium Nitrite demonstrates a diverse range of bioactivities across multiple biological assays. It exhibits significant in vitro activity affecting methemoglobin formation and reductase activity, inducing 100% methemoglobin formation at 1mM concentration and reducing methemoglobin levels at lower concentrations. In cancer research, it shows antiproliferative effects against the human HL60 cell line with an IC50 value of 94000.0 nM. Notably, Sodium Nitrite acts as an inhibitor for several enzymes, including Tyrosyl-DNA Phosphodiesterase (TDP1), ALDH1A1, 15-human lipoxygenase (15-hLO and 15-hLO-2), demonstrating varying potencies. It also functions as an agonist and antagonist in antioxidant response element signaling and ROR-gamma signaling pathways, respectively.
The compound displays broad-spectrum antimicrobial activity, notably against Pseudomonas aeruginosa and various other bacterial strains, inhibiting both under aerobic and anaerobic conditions. Its potential for inhibiting biofilm formation has also been observed. Although it shows substantial inhibitory effects on multiple carbonic anhydrase (CA) enzymes from different species, including human CA1 and CA2, its Ki values vary widely, suggesting selective inhibition across different isoforms and organisms.
Furthermore, Sodium Nitrite has shown antiviral activity against SARS-CoV-2, influencing cytotoxicity and protease functions, and demonstrates neuroprotective effects in rat cortical neuron models against OGD/R-induced apoptosis. Its binding affinity to the beta2 adrenoceptor suggests potential applications in neurological research. Overall, Sodium Nitrite's multifaceted bioactivities suggest its utility in therapeutic development across oncology, microbiology, virology, and enzyme inhibition frameworks..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sodium Nitrite (Nitrous acid, sodium salt) is a compound that is not easy to store and will oxidize to nitric acid if left in the air.Sodium Nitrite has a variety of functions, both oxidizing and reducing, and is very versatile. |
| Targets&IC50 | E. coli:410 mg/L |
| Synonyms | Nitrous acid, sodium salt |
| Molecular Weight | 69.00 |
| Formula | NNaO2 |
| Cas No. | 7632-00-0 |
| Smiles | O=N[O-].[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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