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Sodium Nitrite (Synonyms: Nitrous acid, sodium salt)

Name: Sodium Nitrite
Brand: TargetMol
SKU: T77798
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T77798 Copy Product Info

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Sodium Nitrite (Nitrous acid, sodium salt) is a compound that is not easy to store and will oxidize to nitric acid if left in the air.Sodium Nitrite has a variety of functions, both oxidizing and reducing, and is very versatile.

Sodium Nitrite

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Catalog No. T77798

Synonyms Nitrous acid, sodium salt

Cas No. 7632-00-0

Pack Size	Price	USA Stock	Global Stock
25 mg	$44	In Stock	In Stock
50 mg	$61	In Stock	In Stock
100 mg	$86	In Stock	In Stock
500 mg	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

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Product Introduction

Sodium Nitrite AI Summary

Sodium Nitrite demonstrates a diverse range of bioactivities across multiple biological assays. It exhibits significant in vitro activity affecting methemoglobin formation and reductase activity, inducing 100% methemoglobin formation at 1mM concentration and reducing methemoglobin levels at lower concentrations. In cancer research, it shows antiproliferative effects against the human HL60 cell line with an IC50 value of 94000.0 nM. Notably, Sodium Nitrite acts as an inhibitor for several enzymes, including Tyrosyl-DNA Phosphodiesterase (TDP1), ALDH1A1, 15-human lipoxygenase (15-hLO and 15-hLO-2), demonstrating varying potencies. It also functions as an agonist and antagonist in antioxidant response element signaling and ROR-gamma signaling pathways, respectively. The compound displays broad-spectrum antimicrobial activity, notably against Pseudomonas aeruginosa and various other bacterial strains, inhibiting both under aerobic and anaerobic conditions. Its potential for inhibiting biofilm formation has also been observed. Although it shows substantial inhibitory effects on multiple carbonic anhydrase (CA) enzymes from different species, including human CA1 and CA2, its Ki values vary widely, suggesting selective inhibition across different isoforms and organisms. Furthermore, Sodium Nitrite has shown antiviral activity against SARS-CoV-2, influencing cytotoxicity and protease functions, and demonstrates neuroprotective effects in rat cortical neuron models against OGD/R-induced apoptosis. Its binding affinity to the beta2 adrenoceptor suggests potential applications in neurological research. Overall, Sodium Nitrite's multifaceted bioactivities suggest its utility in therapeutic development across oncology, microbiology, virology, and enzyme inhibition frameworks..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sodium Nitrite (Nitrous acid, sodium salt) is a compound that is not easy to store and will oxidize to nitric acid if left in the air.Sodium Nitrite has a variety of functions, both oxidizing and reducing, and is very versatile.
Targets&IC50	E. coli:410 mg/L
Synonyms	Nitrous acid, sodium salt

Chemical Properties

Molecular Weight	69.00
Formula	NNaO₂
Cas No.	7632-00-0
Smiles	O=N[O-].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (1811.59 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	14.4928 mL	72.4638 mL	144.9275 mL	724.6377 mL
5 mM	2.8986 mL	14.4928 mL	28.9855 mL	144.9275 mL
10 mM	1.4493 mL	7.2464 mL	14.4928 mL	72.4638 mL
20 mM	0.7246 mL	3.6232 mL	7.2464 mL	36.2319 mL
50 mM	0.2899 mL	1.4493 mL	2.8986 mL	14.4928 mL
100 mM	0.1449 mL	0.7246 mL	1.4493 mL	7.2464 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc