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p-Phenylenediamine, N,N'-diphenyl- (Synonyms: NSC-5761, NSC 761, NSC 5761, Flexamine G, DPPD)

Name: p-Phenylenediamine, N,N'-diphenyl-
Brand: TargetMol
SKU: T20093
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T20093 Copy Product Info

Purity: 98.71%

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p-Phenylenediamine, N,N'-diphenyl- (NSC-761) is a bioactive chemical. It has been used to prevent vitamin E deficiency in lambs.

p-Phenylenediamine, N,N'-diphenyl-

Copy Product Info

🥰Excellent

Catalog No. T20093

Synonyms NSC-5761, NSC 761, NSC 5761, Flexamine G, DPPD

p-Phenylenediamine, N,N'-diphenyl- (NSC-761) is a bioactive chemical. It has been used to prevent vitamin E deficiency in lambs.

Cas No. 74-31-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 g	$38	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.71%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

p-Phenylenediamine, N,N'-diphenyl- AI Summary

p-Phenylenediamine, N,N'-diphenyl- demonstrates a broad spectrum of bioactivities, including cytoprotective effects, enzyme inhibition, receptor binding, and impacts on various biochemical parameters. It has shown potent inhibition of cyclooxygenase enzymes COX-1 (IC50 = 260 nM) and COX-2 (IC50 = 580 nM), moderate inhibition of lipoxygenase 15-LO (IC50 = 2883 nM), and strong binding to serotonin 5-HT2B receptors (IC50 and Ki values between 90-142 nM). Additionally, it moderately inhibits the norepinephrine transporter (IC50 and Ki ~ 780-786 nM). The compound exhibits neuroprotective properties in mouse HT22 cells against glutamate-induced oxidative damage with an EC50 of 7.7 nM. It also affects liver and kidney functions, electrolyte balance, lipid metabolism, and various blood cell parameters, and displays multi-target bioactivity disrupting cellular functions and signaling pathways pivotal in metabolism and DNA repair..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	p-Phenylenediamine, N,N'-diphenyl- (NSC-761) is a bioactive chemical. It has been used to prevent vitamin E deficiency in lambs.
Synonyms	NSC-5761, NSC 761, NSC 5761, Flexamine G, DPPD

Chemical Properties

Molecular Weight	260.33
Formula	C₁₈H₁₆N₂
Cas No.	74-31-7
Smiles	N(C1=CC=CC=C1)C1=CC=C(NC2=CC=CC=C2)C=C1
Relative Density.	1.2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (230.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8413 mL	19.2064 mL	38.4128 mL	192.0639 mL
5 mM	0.7683 mL	3.8413 mL	7.6826 mL	38.4128 mL
10 mM	0.3841 mL	1.9206 mL	3.8413 mL	19.2064 mL
20 mM	0.1921 mL	0.9603 mL	1.9206 mL	9.6032 mL
50 mM	0.0768 mL	0.3841 mL	0.7683 mL	3.8413 mL
100 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9206 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

pPhenylenediamine, N,N'diphenylp-Phenylenediamine, N,N'-diphenyl-p Phenylenediamine, N,N' diphenyl NSC-761NSC761NSC5761

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