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HZ1

Name: HZ1
Brand: TargetMol
SKU: T89049
Rating: 4.5 (1 reviews)

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Catalog No. T89049Cas No. 3030492-40-8

Anticanceragent 241 (HZ1) is a novel orally active inhibitor specifically targeting cell cycle-dependent kinase-like 3 (CDKL3). It demonstrates potent antitumor effects and has the potential to overcome resistance to CDK4/6 inhibitors.

HZ1

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Catalog No. T89049Cas No. 3030492-40-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	4-6 weeks	4-6 weeks
50 mg	$1,980	4-6 weeks	4-6 weeks
100 mg	$2,500	4-6 weeks	4-6 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Anticanceragent 241 (HZ1) is a novel orally active inhibitor specifically targeting cell cycle-dependent kinase-like 3 (CDKL3). It demonstrates potent antitumor effects and has the potential to overcome resistance to CDK4/6 inhibitors.
In vitro	Anticancer agent 241 (HZ1; 100 nM) notably diminishes the levels of pRb and CDK4, effectively inducing cell cycle arrest and tumor cell death.
In vivo	Anticancer agent 241 (HZ1; 1 mg/kg; oral gavage; daily for 12-14 days) exhibits anticancer activity in a mouse colon cancer model.

Chemical Properties

Molecular Weight	362.43
Formula	C₂₀H₂₂N₆O
Cas No.	3030492-40-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc