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18β-Glycyrrhetinic acid (Standard)
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Catalog No. TMSM-1592Cas No. 471-53-4
Alias Glycyrrhetinic acid (Standard)
18β-Glycyrrhetinic acid (Standard) is the certified analytical reference standard of 18β-Glycyrrhetinic acid intended for quantitative and analytical research, representing the principal bioactive metabolite of Glycyrrhiza uralensis and exhibiting anti-ulcerative, anti-inflammatory, and antiproliferative properties relevant to pharmacological and natural product studies.
18β-Glycyrrhetinic acid (Standard)
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Catalog No. TMSM-1592Alias Glycyrrhetinic acid (Standard)Cas No. 471-53-4
18β-Glycyrrhetinic acid (Standard) is the certified analytical reference standard of 18β-Glycyrrhetinic acid intended for quantitative and analytical research, representing the principal bioactive metabolite of Glycyrrhiza uralensis and exhibiting anti-ulcerative, anti-inflammatory, and antiproliferative properties relevant to pharmacological and natural product studies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $39 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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| Description | 18β-Glycyrrhetinic acid (Standard) is the certified analytical reference standard of 18β-Glycyrrhetinic acid intended for quantitative and analytical research, representing the principal bioactive metabolite of Glycyrrhiza uralensis and exhibiting anti-ulcerative, anti-inflammatory, and antiproliferative properties relevant to pharmacological and natural product studies. |
| In vivo | In vivo, the most significant systemic effect of 18β-Glycyrrhetinic acid is the induction of pseudo-hyperaldosteronism. By inhibiting renal 11β-HSD2, the compound prevents the inactivation of cortisol, allowing it to bind to the Mineralocorticoid Receptor (MR). Beyond its endocrine effects, the molecule demonstrates gastroprotective activity by promoting mucus secretion and anti-ulcer effects by extending the biological half-life of endogenous steroids [1][2]. |
| Synonyms | Glycyrrhetinic acid (Standard) |
| Molecular Weight | 470.68 |
| Formula | C30H46O4 |
| Cas No. | 471-53-4 |
| Smiles | C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H] |
| Relative Density. | 0.9967 g/cm3 (Estimated) |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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