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Clofibrate

Name: Clofibrate
Brand: TargetMol
SKU: T1298
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1298Cas No. 637-07-0

Alias Ethyl clofibrate, Clofibratum, Clofibrato

Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.

Clofibrate

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Purity: 98.77%

Catalog No. T1298Alias Ethyl clofibrate, Clofibratum, ClofibratoCas No. 637-07-0

Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$44	In Stock	In Stock
1 g	$53	In Stock	In Stock
5 g	$74	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.77%

Appearance:Liquid

Color:Transparent

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COA HNMR GC LCMS

Product Introduction

Clofibrate AI Summary

Clofibrate exhibits a broad spectrum of bioactivities with significant potential in lipid metabolism and liver health management. It demonstrates notable hypolipidemic activity by significantly lowering plasma triglycerides and total cholesterol levels in both hypercholesterolemic and normocholesterolemic rat models. For instance, in cholesterol-fed rats at a 200 mg/kg dose over 3 days, it reduced plasma triglycerides by 10.0%, total cholesterol by 30.0%, and HDL cholesterol by 10.0%. In addition to its hypolipidemic properties, Clofibrate also shows promising antioxidant and hepatoprotective effects. It decreases serum lipid peroxidation levels and enhances antioxidant enzymes like CAT, MDA, and SOD in serum and liver tissues. The compound further demonstrates hypoglycemic activity in KK-mice and significant impacts on enzyme activities related to lipid metabolism, including inhibition of HMG-CoA reductase and enhancement of liver microsomal protein levels. Clofibrate affects plasma lipoprotein ratios, increases liver weight, and shows inhibition of cholesterol and fatty acid biosynthesis, indicating its broader implications on liver function and lipid storage. Additionally, it exhibits considerable binding affinity and inhibitory action against various enzymes and receptors, including human PPAR alpha and gamma, DRD1, and multiple cytochrome P450 isoforms. While these bioactivities suggest therapeutic potential, Clofibrate also shows some toxicity at higher doses, such as a dose-dependent increase in liver weight and minor hepatotoxicity in specific rat models. It exhibits moderate effects against SARS-CoV-2 induced cytotoxicity, highlighting its versatile bioactivity profile but with limited antiviral potency. Overall, Clofibrate presents potential applications in managing dyslipidemia, enhancing antioxidant defense, and possibly modulating lipid-related metabolic pathways, with considerations for its dose-dependent toxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
Targets&IC50	PPARγ (human):500 μM (ec50), PPARα (human):55 μM(ec50), PPARγ (murine):500 μM (ec50), PPARα (murine):50 μM (ec50)
Synonyms	Ethyl clofibrate, Clofibratum, Clofibrato

Chemical Properties

Molecular Weight	242.70
Formula	C₁₂H₁₅ClO₃
Cas No.	637-07-0
Smiles	CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1
Relative Density.	1.14g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (206.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1203 mL	20.6016 mL	41.2031 mL	206.0157 mL
5 mM	0.8241 mL	4.1203 mL	8.2406 mL	41.2031 mL
10 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
20 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
50 mM	0.0824 mL	0.4120 mL	0.8241 mL	4.1203 mL
100 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc