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PS 48

🥰Excellent
Catalog No. T3163Cas No. 1180676-32-7

PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).

PS 48

PS 48

🥰Excellent
Purity: 99.96%
Catalog No. T3163Cas No. 1180676-32-7
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$64In Stock
25 mg$122In Stock
50 mg$178In Stock
100 mg$268In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Batch Information

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Purity:99.96%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
Chemical Properties
Molecular Weight286.75
FormulaC17H15ClO2
Cas No.1180676-32-7
SmilesC(\CCC1=CC=C(Cl)C=C1)(=C/C(O)=O)/C2=CC=CC=C2
Relative Density.1.225 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 50 mM, Sonication is recommended.
DMSO: 55 mg/mL (191.8 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.97 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.4874 mL17.4368 mL34.8736 mL174.3679 mL
5 mM0.6975 mL3.4874 mL6.9747 mL34.8736 mL
10 mM0.3487 mL1.7437 mL3.4874 mL17.4368 mL
20 mM0.1744 mL0.8718 mL1.7437 mL8.7184 mL
50 mM0.0697 mL0.3487 mL0.6975 mL3.4874 mL
DMSO
1mg5mg10mg50mg
100 mM0.0349 mL0.1744 mL0.3487 mL1.7437 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PS-48PS48PS 48PDK1
Related Tags: buy PS 48 | purchase PS 48 | PS 48 cost | order PS 48 | PS 48 chemical structure | PS 48 formula | PS 48 molecular weight
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