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NH-3

Name: NH-3
Brand: TargetMol
SKU: T40548
Price: 229 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40548Cas No. 447415-26-1

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

NH-3

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Purity: 99.40%

Catalog No. T40548Cas No. 447415-26-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$229	In Stock	In Stock
5 mg	$578	In Stock	In Stock
10 mg	$833	In Stock	In Stock
25 mg	$1,270	In Stock	In Stock
50 mg	$1,690	In Stock	In Stock
100 mg	$2,290	-	In Stock
500 mg	$4,620	-	In Stock
1 mL x 10 mM (in DMSO)	$518	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.40%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Targets&IC50	THR:55 nM (IC50)
In vivo	Administration of NH3 (46.2-27,700 nmol/kg/day; 7 days) modestly reduces heart rate beginning at a dose of 46.2 nmol/kg/day, with this effect dissipating at doses exceeding 2920 nmol/kg/day. NH3 does not influence the cholesterol-reducing properties of T3 at 46.2 nmol/kg/day. However, it does obstruct the increase in heart rate and suppression of TSH caused by T3 up to a dosage of 924 nmol/kg/day [2].

Chemical Properties

Molecular Weight	473.52
Formula	C₂₈H₂₇NO₆
Cas No.	447415-26-1
Smiles	CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (200.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5592 mL	21.1184 mL	105.5922 mL
5 mM	0.4224 mL	2.1118 mL	4.2237 mL	21.1184 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5592 mL
20 mM	0.1056 mL	0.5280 mL	1.0559 mL	5.2796 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc