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NH-3

Name: NH-3
Brand: TargetMol
SKU: T40548
Price: 229 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40548Cas No. 447415-26-1

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

NH-3

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Purity: 99.40%

Catalog No. T40548Cas No. 447415-26-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$229	In Stock	In Stock
5 mg	$578	In Stock	In Stock
10 mg	$833	In Stock	In Stock
25 mg	$1,270	In Stock	In Stock
50 mg	$1,690	In Stock	In Stock
100 mg	$2,290	In Stock	In Stock
500 mg	$4,620	-	In Stock
1 mL x 10 mM (in DMSO)	$518	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.40%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Targets&IC50	THR:55 nM (IC50)
In vivo	Administration of NH3 (46.2-27,700 nmol/kg/day; 7 days) modestly reduces heart rate beginning at a dose of 46.2 nmol/kg/day, with this effect dissipating at doses exceeding 2920 nmol/kg/day. NH3 does not influence the cholesterol-reducing properties of T3 at 46.2 nmol/kg/day. However, it does obstruct the increase in heart rate and suppression of TSH caused by T3 up to a dosage of 924 nmol/kg/day [2].

Chemical Properties

Molecular Weight	473.52
Formula	C₂₈H₂₇NO₆
Cas No.	447415-26-1
Smiles	CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (200.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1118 mL	10.5592 mL	21.1184 mL	105.5922 mL
5 mM	0.4224 mL	2.1118 mL	4.2237 mL	21.1184 mL
10 mM	0.2112 mL	1.0559 mL	2.1118 mL	10.5592 mL
20 mM	0.1056 mL	0.5280 mL	1.0559 mL	5.2796 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1118 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc