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NH-3

Catalog No. T40548 CAS 447415-26-1

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

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NH-3, CAS 447415-26-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 229.00
5 mg	In stock	$ 578.00
10 mg	In stock	$ 833.00
25 mg	In stock	$ 1,270.00
50 mg	In stock	$ 1,690.00
100 mg	In stock	$ 2,290.00
500 mg	In stock	$ 4,620.00
1 mL * 10 mM (in DMSO)	In stock	$ 518.00

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Biological Description

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Storage & Solubility Information

Description	NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
Targets&IC50	THR:55 nM (IC50)
In vivo	Administration of NH3 (46.2-27,700 nmol/kg/day; 7 days) modestly reduces heart rate beginning at a dose of 46.2 nmol/kg/day, with this effect dissipating at doses exceeding 2920 nmol/kg/day. NH3 does not influence the cholesterol-reducing properties of T3 at 46.2 nmol/kg/day. However, it does obstruct the increase in heart rate and suppression of TSH caused by T3 up to a dosage of 924 nmol/kg/day [2].

Molecular Weight	473.52
Formula	C28H27NO6
CAS No.	447415-26-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (200.63 mM), Sonification is recommended.

References and Literature

1. Latika Singh, et al. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81(5):1870-6. 2. Gary J Grover, et al. Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther. 2007 Jul;322(1):385-90. 3. Wayland Lim, et al. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem. 2002 Sep 20;277(38):35664-70.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Nuclear Receptor Compound Library Bioactive Compounds Library Max Orally Active Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

L-Thyroxine sodium (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate 2-Thiouracil Glutaurine aceate Methimazole L-Thyroxine Protirelin Acetate(24305-27-9 free base) DS08210767

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Keywords

NH-3 447415-26-1 Endocrinology/Hormones Thyroid hormone receptor(THR) Inhibitor NH 3 orally thyromi-metic inhibit GC-1 recruitment Thyroid Hormone Receptor THR NH3 cofactor inhibitor

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