ED 50 < 50.0 ng/ml, measured by a cell proliferation assay using MCF-7 cells, corresponding to a specific activity of > 2.0 × 10 4 units/mg.

IL-19 Protein, Mouse, Recombinant is expressed in E. coli. The accession number is Q8CJ70.

Mouse

E. coli

ZMDA1,NG.1,Melanoma differentiation association like protein,MDA1,IL19,IL-10C

Leu25-Ala176

> 95% as determined by SDS-PAGE

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in 50 mM acetic acid up to 50 μg/ml.

Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Interleukin-19 (IL-19) is a cytokine belonging to the interleukin family. Structurally, IL-19 is grouped into the IL-10 sub-family, which also includes IL-20, IL-22, IL-24, and IL-26. In contrast to IL-10, which exists as a homodimer, IL-19 is stable and active as a monomer in vivo. IL-19 functions through the receptor complex composed of IL-20 Receptor α and IL-20 Receptor β, which is also utilized by IL-20 and IL-24. IL-19 is produced by active monocytes and stimulated synergistically by IL-17 and IL-13. The functions of IL-19 are to promote the development and function of Th2 cells and to enhance the production of Th2 cytokines. IL-19 is implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.