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Orthanilamide

Name: Orthanilamide
Brand: TargetMol
SKU: T2187
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2187Cas No. 3306-62-5

Alias O-Sulfanilamide, Benzenesulfonamide, 2-Aminobenzenesulfonamide

Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.

Orthanilamide

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Purity: 99.96%

Catalog No. T2187Alias O-Sulfanilamide, Benzenesulfonamide, 2-AminobenzenesulfonamideCas No. 3306-62-5

Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$39	In Stock	In Stock
100 mg	$54	In Stock	In Stock
200 mg	$83	-	In Stock
500 mg	$138	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Orthanilamide AI Summary

Orthanilamide exhibits bioactivity as an inhibitor of various carbonic anhydrase (CA) enzymes with differing potencies. It shows significant inhibition against human carbonic anhydrase II (Ki = 295.0 nM) and notable activity against human carbonic anhydrase IX (Ki = 33.0 nM). It also demonstrates inhibitory effects on human carbonic anhydrase I (Ki = 45400.0 nM) and bovine carbonic anhydrase IV (Ki = 1310.0 nM). Additionally, Orthanilamide has been observed to inhibit helicobacter pylori recombinant carbonic anhydrase (Ki = 426.0 nM) and exhibits selectivity for different CA isoforms, suggesting potential application as a multi-target CA inhibitor with therapeutic implications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.
Synonyms	O-Sulfanilamide, Benzenesulfonamide, 2-Aminobenzenesulfonamide

Chemical Properties

Molecular Weight	172.2
Formula	C₆H₈N₂O₂S
Cas No.	3306-62-5
Smiles	NC1=CC=CC=C1S(N)(=O)=O
Relative Density.	1.427g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (261.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (29.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8072 mL	29.0360 mL	58.0720 mL	290.3600 mL
5 mM	1.1614 mL	5.8072 mL	11.6144 mL	58.0720 mL
10 mM	0.5807 mL	2.9036 mL	5.8072 mL	29.0360 mL
20 mM	0.2904 mL	1.4518 mL	2.9036 mL	14.5180 mL
50 mM	0.1161 mL	0.5807 mL	1.1614 mL	5.8072 mL
100 mM	0.0581 mL	0.2904 mL	0.5807 mL	2.9036 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc