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ML 120B dihydrochloride (Synonyms: ML-120B dihydrochloride, ML120B dihydrochloride)

Name: ML 120B dihydrochloride
Brand: TargetMol
SKU: T39199
Rating: 4.5 (1 reviews)

Catalog No. T39199 Copy Product Info

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ML 120B dihydrochloride is an effective ATP competitive IKKβ inhibitor with oral activity, and its IC₅₀ is 60 nM. ML 120B dihydrochloride can inhibit the growth of multiple myeloma cells and can be used in the related research of rheumatoid arthritis.

ML 120B dihydrochloride

Copy Product Info

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Catalog No. T39199

Synonyms ML-120B dihydrochloride, ML120B dihydrochloride

Cas No. 1782573-78-7

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$155	5 days	5 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	ML 120B dihydrochloride is an effective ATP competitive IKKβ inhibitor with oral activity, and its IC₅₀ is 60 nM. ML 120B dihydrochloride can inhibit the growth of multiple myeloma cells and can be used in the related research of rheumatoid arthritis.
Targets&IC50	IKKβ:60 nM
In vitro	In RPMI 8226 and INA6 cells, ML 120B dihydrochloride (0–20 μM; 90 minutes) inhibits TNF-α-induced phosphorylation and degradation of IκB and blocks TNF-α-induced phosphorylation of p65 NF-κB [1]. ML 120B dihydrochloride inhibits the proliferation of various multiple myeloma cell lines (MM.1S, MM.1R, RPMI 8226, RPMI-LR5, RPMI-Dox40, U266, and INA6 cells) [1]. ML 120B dihydrochloride inhibits LPS-induced NF-κB activation in RAW267.4 cells. For cells transfected with NF-κB2-luc2, IL8-luc2, or TNF-AIP3-luc2 reporter genes, the IC50 values of ML 120B dihydrochloride were 1.4 μM, 14.8 μM, and 27.3 μM, respectively [3].
In vivo	ML 120B dihydrochloride, administered orally at a dosage of 50 mg/kg twice daily for three weeks, has been shown to significantly reduce shuIL-6R, a key marker of tumor growth, in two separate studies, thereby indicating its efficacy in suppressing tumor progression. Furthermore, this treatment has demonstrated a trend towards prolonged survival in treated animals when compared to controls, suggesting its potential therapeutic benefit in oncological contexts[1][3]. Implemented in an animal model involving SCID mice implanted with human fetal bone chips and subsequently inoculated with INA6 cells, ML 120B dihydrochloride inhibited human multiple myeloma cell growth in vivo. Additionally, in a study with two-month-old female Lewis rats administered varying dosages (30 mg/kg, 10 mg/kg, 3 mg/kg, or 1 mg/kg) of ML 120B dihydrochloride orally twice daily for three weeks, it was found to protect against bone and cartilage destruction in a rat model of disease, further evidencing its potential for broader applications in disease treatment and management[2].
Synonyms	ML-120B dihydrochloride, ML120B dihydrochloride

Chemical Properties

Molecular Weight	439.72
Formula	C₁₉H₁₇Cl₃N₄O₂
Cas No.	1782573-78-7
Smiles	O=C(C1=CC=CN=C1C)NC2=C(C(Cl)=CC3=C2NC4=C3C=CN=C4)OC.Cl.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (37.91 mM), when pH is adjusted to 8 with NaOH.Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2742 mL	11.3709 mL	22.7417 mL	113.7087 mL
5 mM	0.4548 mL	2.2742 mL	4.5483 mL	22.7417 mL
10 mM	0.2274 mL	1.1371 mL	2.2742 mL	11.3709 mL
20 mM	0.1137 mL	0.5685 mL	1.1371 mL	5.6854 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc