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2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one

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Catalog No. T8602Cas No. 13947-21-2

2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one targets the Neutrophil elastase (human).

2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one

2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one

😃Good
Catalog No. T8602Cas No. 13947-21-2
2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one targets the Neutrophil elastase (human).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30InquiryInquiry
5 mg$43InquiryInquiry
10 mg$61InquiryInquiry
25 mg$110InquiryInquiry
50 mg$165InquiryInquiry
100 mg$248InquiryInquiry
200 mg$368InquiryInquiry
1 mL x 10 mM (in DMSO)$46InquiryInquiry
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Product Introduction

Bioactivity
Description
2-Chloromethyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one targets the Neutrophil elastase (human).
Chemical Properties
Molecular Weight231.66
FormulaC8H6ClNO3S
Cas No.13947-21-2
SmilesO=C1C=2C(S(=O)(=O)N1CCl)=CC=CC2
Relative Density.1.596g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (118.71 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3167 mL21.5834 mL43.1667 mL215.8335 mL
5 mM0.8633 mL4.3167 mL8.6333 mL43.1667 mL
10 mM0.4317 mL2.1583 mL4.3167 mL21.5834 mL
20 mM0.2158 mL1.0792 mL2.1583 mL10.7917 mL
50 mM0.0863 mL0.4317 mL0.8633 mL4.3167 mL
100 mM0.0432 mL0.2158 mL0.4317 mL2.1583 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SerineProteaseSerine ProteaseNeutrophil elastase (human)2CHLOROMETHYL1,1DIOXO1,2DIHYDRO1LAMBDA*6*BENZO[D]ISOTHIAZOL3ONE2 CHLOROMETHYL 1,1 DIOXO 1,2 DIHYDRO 1LAMBDA*6* BENZO[D]ISOTHIAZOL 3 ONE
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