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m-PEG12-amine

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Catalog No. T15839Cas No. 1977493-48-3

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].

m-PEG12-amine

m-PEG12-amine

🥰Excellent
Catalog No. T15839Cas No. 1977493-48-3
m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$48-In Stock
50 mg$77-In Stock
100 mg$118-In Stock
200 mg$173-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:>99.99%
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Product Introduction

Bioactivity
Description
m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].
In vitro
PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.
Chemical Properties
Molecular Weight559.69
FormulaC25H53NO12
Cas No.1977493-48-3
SmilesC(OCCOCCOCCOCCOCCOCCN)COCCOCCOCCOCCOCCOC
Relative Density.1.073 g/cm3 (Predicted)
ColorWhite
AppearanceLiquid
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (160.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7867 mL8.9335 mL17.8670 mL89.3352 mL
5 mM0.3573 mL1.7867 mL3.5734 mL17.8670 mL
10 mM0.1787 mL0.8934 mL1.7867 mL8.9335 mL
20 mM0.0893 mL0.4467 mL0.8934 mL4.4668 mL
50 mM0.0357 mL0.1787 mL0.3573 mL1.7867 mL
100 mM0.0179 mL0.0893 mL0.1787 mL0.8934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PROTAC LinkersPEGsNon-cleavablem-PEG12-aminem-PEG-12-aminemPEG12aminem PEG12 amineADCLinkerADC linkerADC Linker
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