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Actinonin

Name: Actinonin
Brand: TargetMol
SKU: T14121
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14121Cas No. 13434-13-4

Alias (-)-Actinonin

Actinonin is a natural antibacterial agent produced by Streptomyces, also serving as an effective PDF (peptide deformylase) inhibitor and apoptosis inducer. It inhibits APN (Aminopeptidase N), MMPs and heparin α, exhibiting antiproliferative and antitumour activity.

Actinonin

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Purity: 99.74%

Catalog No. T14121Alias (-)-ActinoninCas No. 13434-13-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	-	In Stock
2 mg	$50	-	In Stock
5 mg	$81	-	In Stock
10 mg	$147	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Actinonin is a natural antibacterial agent produced by Streptomyces, also serving as an effective PDF (peptide deformylase) inhibitor and apoptosis inducer. It inhibits APN (Aminopeptidase N), MMPs and heparin α, exhibiting antiproliferative and antitumour activity.
Targets&IC50	MMP9:330 nM (Ki), MMP8:190 nM (Ki), MMP3:1700 nM (Ki), MMP1:300 nM (Ki), Peptide deformylase:0.28 nM (Ki), hmeprin α:20 nM (Ki)
In vitro	Actinonin exhibits significant proliferation-inhibitory effects on 16 tumor cell lines, with IC₅₀ values ranging from 5 to 60 μM, showing dose- and time-dependent characteristics, while demonstrating no significant impact on normal cell lines (such as WI-38, NIH-3T3, and hPBMCs) [1]. Treatment of RL lymphoma cells with Actinonin (10-100 μg/ml) induces time-dependent and dose-dependent mitochondrial membrane depolarization, with membrane potential recovering approximately 8 hours after Actinonin removal, suggesting its mechanism of action is mediated through indirect effects on the electron transport chain [1].
In vivo	In the CWR22 human prostate cancer model, both intraperitoneal injection (250 mg/kg) and oral administration (500 mg/kg) of Actinonin significantly inhibited tumor growth. The significant effect of oral administration indicates that Actinonin has good oral bioavailability [1].
Synonyms	(-)-Actinonin

Chemical Properties

Molecular Weight	385.5
Formula	C₁₉H₃₅N₃O₅
Cas No.	13434-13-4
Smiles	C([C@@H](NC([C@@H](CC(NO)=O)CCCCC)=O)[C@@H](C)C)(=O)N1[C@H](CO)CCC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (103.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (10.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5940 mL	12.9702 mL	25.9403 mL	129.7017 mL
5 mM	0.5188 mL	2.5940 mL	5.1881 mL	25.9403 mL
10 mM	0.2594 mL	1.2970 mL	2.5940 mL	12.9702 mL
20 mM	0.1297 mL	0.6485 mL	1.2970 mL	6.4851 mL
50 mM	0.0519 mL	0.2594 mL	0.5188 mL	2.5940 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	1.2970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc