Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | In stock | $ 698.00 | |
500 μg | 5 days | $ 2,800.00 | |
1 mg | 5 days | $ 4,650.00 |
Biological Information | Immobilized Rat GDF15, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Mouse GFRAL, His Tag with the EC50 of 0.95μg/ml determined by ELISA. |
Description | Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. |
Species | Rat |
Expression System | E. coli |
Tag | N-His |
Accession Number | Q9Z0J6 |
Synonyms | GDF-15, PDF, PTGF-beta, MIC-1, MIC1, GDF15, PTGFBPTGF-beta, NAG-1, Placental TGF-β, PTGF-β, PLAB, PTGFBPTGF-β, Placental TGF-beta, PTGFB, RG-1 |
Construction | Recombinant Rat GDF15 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Ser189-Ala303.[Accession |Q9Z0J6] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 13.68 kDa. The protein migrates to 15-17 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in 50mM HAc (pH 2.9). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9). |
Stability & Storage |
-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15. |
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Please read the User Guide of Recombinant Proteins for more specific information.
GDF-15 Protein, Rat, Recombinant (His) PTGF-b GDF-15 RG 1 RG1 PTGFBPTGF-b PDF PTGF-beta Placental TGF-b MIC-1 MIC1 GDF15 GDF 15 PTGFBPTGF-beta NAG-1 Placental TGF-β PTGF-β NAG 1 PLAB PTGFBPTGF-β Placental TGF-beta PTGFB MIC 1 NAG1 RG-1 recombinant recombinant-proteins proteins protein