Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Zatebradine

Name: Zatebradine
Brand: TargetMol
SKU: T13387
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T13387Cas No. 85175-67-3

Alias UL-FS-49CL free base, UL-FS-49 free base

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

Zatebradine

Copy Product Info

😃Good

Catalog No. T13387Alias UL-FS-49CL free base, UL-FS-49 free baseCas No. 85175-67-3

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$88	5 days	5 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
Targets&IC50	HCN:1.96 µM
In vitro	Zatebradine exhibits a use-dependent blockade of the cardiac pacemaker current in rabbit sino-atrial node cells (Kd 480 nM) [2].
In vivo	In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1].
Synonyms	UL-FS-49CL free base, UL-FS-49 free base

Chemical Properties

Molecular Weight	456.57
Formula	C₂₆H₃₆N₂O₅
Cas No.	85175-67-3
Smiles	COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Relative Density.	1.115g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1902 mL	10.9512 mL	21.9024 mL	109.5122 mL
5 mM	0.4380 mL	2.1902 mL	4.3805 mL	21.9024 mL
10 mM	0.2190 mL	1.0951 mL	2.1902 mL	10.9512 mL
20 mM	0.1095 mL	0.5476 mL	1.0951 mL	5.4756 mL
50 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1902 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0951 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc