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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $88 | 5 days |
Description | Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM). |
Targets&IC50 | HCN:1.96 µM |
In vitro | Zatebradine exhibits a use-dependent blockade of the cardiac pacemaker current in rabbit sino-atrial node cells (Kd 480 nM) [2]. |
In vivo | In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1]. |
Alias | UL-FS-49 free base, UL-FS-49CL free base |
Molecular Weight | 456.57 |
Formula | C26H36N2O5 |
Cas No. | 85175-67-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (109.51 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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