Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Zatebradine

Name: Zatebradine
Brand: TargetMol
SKU: T13387
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T13387Cas No. 85175-67-3

Alias UL-FS-49CL free base, UL-FS-49 free base

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

Zatebradine

😃Good

Catalog No. T13387Alias UL-FS-49CL free base, UL-FS-49 free baseCas No. 85175-67-3

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$88	5 days	5 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
Targets&IC50	HCN:1.96 µM
In vitro	Zatebradine exhibits a use-dependent blockade of the cardiac pacemaker current in rabbit sino-atrial node cells (Kd 480 nM) [2].
In vivo	In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1].
Synonyms	UL-FS-49CL free base, UL-FS-49 free base

Chemical Properties

Molecular Weight	456.57
Formula	C₂₆H₃₆N₂O₅
Cas No.	85175-67-3
Relative Density.	1.115g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.48 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1902 mL	10.9512 mL	21.9024 mL	109.5122 mL
5 mM	0.4380 mL	2.1902 mL	4.3805 mL	21.9024 mL
10 mM	0.2190 mL	1.0951 mL	2.1902 mL	10.9512 mL
20 mM	0.1095 mL	0.5476 mL	1.0951 mL	5.4756 mL
50 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1902 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0951 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc