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Zatebradine

Zatebradine
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
Catalog No. T13387Cas No. 85175-67-3

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Zatebradine

Catalog No. T13387Cas No. 85175-67-3

Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
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2 mg$885 days
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Product Introduction

Bioactivity
Description
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM).
Targets&IC50
HCN:1.96 µM
In vitro
Zatebradine exhibits a use-dependent blockade of the cardiac pacemaker current in rabbit sino-atrial node cells (Kd 480 nM) [2].
In vivo
In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1].
AliasUL-FS-49 free base, UL-FS-49CL free base
Chemical Properties
Molecular Weight456.57
FormulaC26H36N2O5
Cas No.85175-67-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (109.51 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1902 mL10.9512 mL21.9024 mL109.5122 mL
5 mM0.4380 mL2.1902 mL4.3805 mL21.9024 mL
10 mM0.2190 mL1.0951 mL2.1902 mL10.9512 mL
20 mM0.1095 mL0.5476 mL1.0951 mL5.4756 mL
50 mM0.0438 mL0.2190 mL0.4380 mL2.1902 mL
100 mM0.0219 mL0.1095 mL0.2190 mL1.0951 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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