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GLPG0974

Name: GLPG0974
Brand: TargetMol
SKU: T15388
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15388Cas No. 1391076-61-1

Alias GLPG-0974

GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.

GLPG0974

🥰Excellent

Purity: 99.8%

Catalog No. T15388Alias GLPG-0974Cas No. 1391076-61-1

GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$589	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.8%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
Targets&IC50	GPR43:9 nM
In vitro	GLPG0974 inhibits acetate-induced neutrophil migration strongly and inhibits CD11b activation-specific epitope [AE], a neutrophil-based pharmacodynamic marker, in a human whole blood assay[1].
In vivo	GLPG0974(5 and 30 mg/kg; oral) exhibits good pharmacokinetic properties in rat with a bioavailability of 47% and dose-dependently increases the plasma exposure[1].
Synonyms	GLPG-0974

Chemical Properties

Molecular Weight	484.99
Formula	C₂₅H₂₅ClN₂O₄S
Cas No.	1391076-61-1
Smiles	C[C@@]1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1
Relative Density.	1.374 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257 mg/mL (529.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (10.31 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0619 mL	10.3095 mL	20.6190 mL	103.0949 mL
5 mM	0.4124 mL	2.0619 mL	4.1238 mL	20.6190 mL
10 mM	0.2062 mL	1.0309 mL	2.0619 mL	10.3095 mL
20 mM	0.1031 mL	0.5155 mL	1.0309 mL	5.1547 mL
50 mM	0.0412 mL	0.2062 mL	0.4124 mL	2.0619 mL
100 mM	0.0206 mL	0.1031 mL	0.2062 mL	1.0309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc