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GLPG0974

🥰Excellent
Catalog No. T15388Cas No. 1391076-61-1
Alias GLPG-0974

GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.

GLPG0974

GLPG0974

🥰Excellent
Purity: 99.8%
Catalog No. T15388Alias GLPG-0974Cas No. 1391076-61-1
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$51In StockIn Stock
5 mg$122In StockIn Stock
10 mg$197In StockIn Stock
25 mg$396In StockIn Stock
50 mg$589In StockIn Stock
1 mL x 10 mM (in DMSO)$128In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.8%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
Targets&IC50
GPR43:9 nM
In vitro
GLPG0974 inhibits acetate-induced neutrophil migration strongly and inhibits CD11b activation-specific epitope [AE], a neutrophil-based pharmacodynamic marker, in a human whole blood assay[1].
In vivo
GLPG0974(5 and 30 mg/kg; oral) exhibits good pharmacokinetic properties in rat with a bioavailability of 47% and dose-dependently increases the plasma exposure[1].
SynonymsGLPG-0974
Chemical Properties
Molecular Weight484.99
FormulaC25H25ClN2O4S
Cas No.1391076-61-1
SmilesC[C@@]1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1
Relative Density.1.374 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 257 mg/mL (529.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0619 mL10.3095 mL20.6190 mL103.0949 mL
5 mM0.4124 mL2.0619 mL4.1238 mL20.6190 mL
10 mM0.2062 mL1.0309 mL2.0619 mL10.3095 mL
20 mM0.1031 mL0.5155 mL1.0309 mL5.1547 mL
50 mM0.0412 mL0.2062 mL0.4124 mL2.0619 mL
100 mM0.0206 mL0.1031 mL0.2062 mL1.0309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GPR43GLPG0974GLPG 0974FFA2
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