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Anti-DKC1 Antibody (3S961)

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Catalog No. TMAB-05174

Anti-DKC1 Antibody (3S961) is a Rabbit antibody targeting DKC1. Anti-DKC1 Antibody (3S961) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.

Anti-DKC1 Antibody (3S961)

Anti-DKC1 Antibody (3S961)

😃Good
Catalog No. TMAB-05174
Anti-DKC1 Antibody (3S961) is a Rabbit antibody targeting DKC1. Anti-DKC1 Antibody (3S961) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4707-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-DKC1 Antibody (3S961) is a Rabbit antibody targeting DKC1. Anti-DKC1 Antibody (3S961) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, WB.
Ig Type
IgG
Clone
3S961
Reactivity
Human,Mouse (predicted:Rat)
Application
Recommended Dose
FCM=1:50-100; ICC/IF=1:50-200; IF=1:50-200; IHC-Fr=1:100-200; IHC-P=1:100-200; WB=1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm and Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies.
Tissue SpecificityUbiquitously expressed.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundIsoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression.
Antigen Details
Immunogen
A synthesized peptide: human Dyskerin
Antigen Species
Human
Gene Name
DKC1
Gene ID
Protein Name
H/ACA ribonucleoprotein complex subunit DKC1
Uniprot ID
Function
Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Chemical Properties
Molecular WeightTheoretical: 58 kDa. Actual: 58 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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