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Vazegepant

Name: Vazegepant
Brand: TargetMol
SKU: T38734
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38734Cas No. 1337918-83-8

Alias Zavegepant, BMS-742413, BHV-3500

Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.

Vazegepant

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Purity: 98.61%

Catalog No. T38734Alias Zavegepant, BMS-742413, BHV-3500Cas No. 1337918-83-8

Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$239	Backorder
1 mL x 10 mM (in DMSO)	$322	In Stock

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Purity:98.61%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.
Synonyms	Zavegepant, BMS-742413, BHV-3500

Chemical Properties

Molecular Weight	638.80
Formula	C₃₆H₄₆N₈O₃
Cas No.	1337918-83-8
Smiles	O=C1C(=CC=2C(N1)=CC=CC2)C3CCN(C(N[C@H](CC=4C=C5C(=C(C)C4)NN=C5)C(=O)N6CCN(CC6)C7CCN(C)CC7)=O)CC3
Relative Density.	1.285 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (46.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5654 mL	7.8272 mL	15.6544 mL	78.2718 mL
5 mM	0.3131 mL	1.5654 mL	3.1309 mL	15.6544 mL
10 mM	0.1565 mL	0.7827 mL	1.5654 mL	7.8272 mL
20 mM	0.0783 mL	0.3914 mL	0.7827 mL	3.9136 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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