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Vazegepant

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Catalog No. T38734Cas No. 1337918-83-8
Alias Zavegepant, BMS-742413, BHV-3500

Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.

Vazegepant

Vazegepant

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Purity: 99.98%
Catalog No. T38734Alias Zavegepant, BMS-742413, BHV-3500Cas No. 1337918-83-8
Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$97In StockIn Stock
5 mg$239In StockIn Stock
10 mg$353In StockIn Stock
25 mg$597In StockIn Stock
50 mg$852In StockIn Stock
100 mg$1,170-In Stock
1 mL x 10 mM (in DMSO)$322In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Vazegepant (Zavegepant) is an orally available and selective antagonist of the calcitonin gene-related peptide CGRP receptor for pain relief and may be used in the study of migraine.
SynonymsZavegepant, BMS-742413, BHV-3500
Chemical Properties
Molecular Weight638.80
FormulaC36H46N8O3
Cas No.1337918-83-8
SmilesO=C1C(=CC=2C(N1)=CC=CC2)C3CCN(C(N[C@H](CC=4C=C5C(=C(C)C4)NN=C5)C(=O)N6CCN(CC6)C7CCN(C)CC7)=O)CC3
Relative Density.1.285 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (46.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5654 mL7.8272 mL15.6544 mL78.2718 mL
5 mM0.3131 mL1.5654 mL3.1309 mL15.6544 mL
10 mM0.1565 mL0.7827 mL1.5654 mL7.8272 mL
20 mM0.0783 mL0.3914 mL0.7827 mL3.9136 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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