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Small Molecule Inhibitors

Small Molecule Inhibitors

Small molecule inhibitors can bind to target proteins and reduce their biological activity and are often used as tools in biological and pharmacological research.

Small molecule inhibitors have many advantages. For example, they can be easily manipulated and can be applied to a variety of cell or animal experiments; they have good permeability to cross cell membranes easily; they have higher stability, which can reduce the instability in an experiment. Small molecule inhibitors have become important tool drugs in life science research in recent years due to their significant advantages in the regulation of different cellular processes, ranging from cell cycle control and mitosis to signaling pathways and gene expression; and from migration and wound healing, to apoptosis and autophagy.

Targetmol can provide a variety of small molecule inhibitors of hot signaling pathways for research and development.

Signaling Pathways

  Angiogenesis   Apoptosis   Autophagy   Cell Cycle/Checkpoint   Chromatin/Epigenetic   Cytoskeletal Signaling   DNA Damage/DNA Repair   Endocrinology/Hormones   GPCR/G Protein   Immunology/Inflammation   JAK/STAT signaling   MAPK   Membrane transporter/Ion channel   Metabolism   Microbiology/Virology   Neuroscience   NF-Κb   Oxidation-reduction   PI3K/Akt/mTOR signaling   Proteases/Proteasome   Stem Cells   Tyrosine Kinase/Adaptors   Ubiquitination   Others

Angiogenesis

Apoptosis

Autophagy

Cell Cycle/Checkpoint

Chromatin/Epigenetic

Cytoskeletal Signaling

DNA Damage/DNA Repair

Endocrinology/Hormones

GPCR/G Protein

Immunology/Inflammation

JAK/STAT signaling

MAPK

Membrane transporter/Ion channel

Metabolism

Microbiology/Virology

Neuroscience

NF-Κb

Oxidation-reduction

PI3K/Akt/mTOR signaling

Proteases/Proteasome

Stem Cells

Tyrosine Kinase/Adaptors

Ubiquitination

Others

ACAT ( 8) Advanced glycation end pr... ( 4) Decarboxylase ( 6) DprE1 ( 4) Others ( 14992) Platelet aggregation ( 6) Wnk ( 2) BVDV ( 0) Keap1-Nrf ( 1) NKCC ( 0) Salt-Inducible Kinase ( 0) PTP1B ( 0) Progesterone Receptor ( 1) Thyroid Hormone Receptor ( 1) Fer/FerT kinase ( 0) CYP19A1 ( 0) Cathepsin B ( 0) PGK ( 2) Streptokinase ( 34) Hepatitis C virus NS3 pro... ( 1) Vaccinia virus ( 1) High-affinity choline tra... ( 1) Genome polyprotein ( 1) Epstein-Barr nuclear anti... ( 1) Vesicular stomatitis viru... ( 1) Ataxin ( 174) 3C-like protease ( 1) Autoinducer 1 sensor kina... ( 1) Human immunodeficiency vi... ( 5) Human herpesvirus 1 strai... ( 1) Voltage-gated potassium c... ( 1) Malme-3M ( 1) Serotonin 2a (5-HT2a) rec... ( 1) Saccharomyces cerevisiae ( 2) Enoyl-acyl carrier reduct... ( 2) Putative uncharacterized ... ( 1) Egl nine homolog 3 ( 1) Paracentrotus lividus ( 1) SNB-75 ( 1) Candida albicans ( 1) NIH3T3 ( 1) Muscarinic acetylcholine ... ( 1) Cytochrome P450 2D6 ( 1) Ubiquitin-conjugating enz... ( 1) Staphylococcus aureus ( 3) Giardia ( 2) Putative fructose-1,6-bis... ( 2) Trypanosoma brucei rhodes... ( 1) Cannabinoid CB2 receptor ( 1) Trypanosoma brucei brucei ( 6) Toxoplasma gondii RH ( 1) Glycine transporter 2 ( 1) Relaxin receptor 1 ( 1) Phosphoglycerate kinase, ... ( 8) Nucleic Acid ( 2) ORF 73 ( 1) Large T antigen ( 4) Human parainfluenza virus... ( 1) Phosphotyrosine-protein p... ( 1) Enoyl-[acyl-carrier-prote... ( 1) Streptokinase A ( 21) Mycobacterium bovis BCG ( 4) Shiga toxin ( 2) HL-60 ( 1) INS1 ( 1) Smoothened homolog ( 1) Casein kinase I delta ( 0) Isoprenylcysteine carboxy... ( 1) Phosphodiesterase 6D ( 1) Excitatory amino acid tra... ( 1) Heat shock factor protein... ( 1) Sentrin-specific protease... ( 1) Phosphodiesterase 10A ( 1) Tyrosine-protein kinase S... ( 0) Formyl peptide receptor 1 ( 2) Transient receptor potent... ( 2) Macrophage migration inhi... ( 1) Intestinal alkaline phosp... ( 2) Cytochrome P450 17A1 ( 1) Butyrylcholinesterase ( 2) Zinc finger protein GLI1 ( 1) Heparanase ( 1) 1-acylglycerol-3-phosphat... ( 1) Voltage-gated T-type calc... ( 2) DNA dC->dU-editing enzyme... ( 2) Kappa opioid receptor ( 1) Fructose-bisphosphate ald... ( 1) Cytochrome P450 3A4 ( 2) Estrogen receptor alpha ( 2) Voltage-gated T-type calc... ( 3) C-C chemokine receptor ty... ( 2) A498 ( 1) MRC5 ( 2) Trace amine-associated re... ( 4) MDA-MB-468 ( 1) MCF7 ( 1) Prostaglandin E synthase ( 2) Fatty acid transport prot... ( 1) Flap endonuclease 1 ( 2) Matrix metalloproteinase-... ( 1) Nociceptin receptor ( 1) Long-chain fatty acid tra... ( 1) Glycogen synthase kinase-... ( 0) SF-539 ( 1) Peripheral-type benzodiaz... ( 1) HeLa ( 2) SK-BR-3 ( 1) Thioredoxin reductase 1, ... ( 5) Mus musculus ( 2) Tumour suppressor p53/onc... ( 1) Neutrophils ( 2) Breast cancer type 1 susc... ( 6) Alpha-synuclein ( 5) SNB-19 ( 1) No relevant target ( 2) HepG2 ( 4) RAW264.7 ( 2) Menin/Histone-lysine N-me... ( 15) UO-31 ( 1) DNA polymerase eta ( 6) Paired box protein Pax-8 ( 2) DNA dC->dU-editing enzyme... ( 18) Mitogen-activated protein... ( 1) A549 ( 1) DNA polymerase iota ( 36) Cavia porcellus ( 3) Tankyrase-2 ( 2) Plasmodium falciparum ( 419) Protein-glutamine gamma-g... ( 1) Cytochrome P450 19A1 ( 2) MOLT-4 ( 1) Leukocyte elastase ( 1) Xanthine dehydrogenase ( 1) RXF 393 ( 2) SK-MEL-2 ( 1) Cytochrome P450 2C9 ( 2) ATP-dependent molecular c... ( 5) Phosphodiesterase 5A ( 2) T98G ( 4) PI3-kinase p110-alpha sub... ( 0) Isocitrate dehydrogenase ... ( 5) Cyclooxygenase-2 ( 2) MIF/CD74 (Macrophage migr... ( 1) Runt-related transcriptio... ( 5) GABA-A receptor; anion ch... ( 0) Cytochrome P450 2C19 ( 2) NCI-H460 ( 1) OVCAR-5 ( 1) Vascular endothelial grow... ( 0) Aorta ( 2) Ubiquitin carboxyl-termin... ( 1) Vero ( 1) Prostanoid EP2 receptor ( 1) Peptidyl-prolyl cis-trans... ( 1) TAR DNA-binding protein 4... ( 202) Cytochrome P450 1A2 ( 5) Mothers against decapenta... ( 435) Fibroblast growth factor ... ( 1) MicroRNA 21 ( 105) Luciferin 4-monooxygenase ( 35) FAD-linked sulfhydryl oxi... ( 9) Signal transducer and act... ( 1) XF498 ( 2) PI3-kinase p110-delta sub... ( 0) HEK293 ( 557) Histone-lysine N-methyltr... ( 4) Monoamine oxidase B ( 5) Estradiol 17-beta-dehydro... ( 1) Tyrosine-protein kinase A... ( 0) Estrogen receptor beta ( 1) Aldo-keto-reductase famil... ( 2) Neurokinin 3 receptor ( 4) Cytochrome P450 11B2 ( 1) Sigma-1 receptor ( 2) Sigma opioid receptor ( 1) Endothelin-converting enz... ( 1) Testis-specific androgen-... ( 2) Anthrax lethal factor ( 9) Kinesin-like protein 1 ( 2) Peroxisome proliferator-a... ( 1) Tyrosyl-DNA phosphodieste... ( 3) Serotonin 2c (5-HT2c) rec... ( 4) Niemann-Pick C1 protein ( 17) Serotonin 6 (5-HT6) recep... ( 14) Ras-related protein Rab-9... ( 26) Adenosine A1 receptor ( 3) Adenosylmethionine-8-amin... ( 2) Inosine-5'-monophosphate ... ( 1) Bromodomain adjacent to z... ( 11) Lysine-specific demethyla... ( 0) G-protein coupled recepto... ( 1) Dopamine D2 receptor ( 3) Glutaminase kidney isofor... ( 5) Lipoxin A4 receptor ( 3) Arachidonate 15-lipoxygen... ( 2) Melanin-concentrating hor... ( 1) Aberrant vpr protein ( 23) Elongation of very long c... ( 1) Alkaline phosphatase, tis... ( 3) Beta-glucocerebrosidase ( 22) Alpha-galactosidase A ( 5) Nonstructural protein 1 ( 136) Vanilloid receptor ( 2) Metabotropic glutamate re... ( 8) 6-phospho-1-fructokinase ( 0) Neuropeptide S receptor ( 14) 4'-phosphopantetheinyl tr... ( 5) Tumor susceptibility gene... ( 3) Lysine-specific demethyla... ( 2) MAP kinase ERK2 ( 1) FK506 binding protein 12 ( 124) P-glycoprotein 1 ( 5) ATP-dependent DNA helicas... ( 9) Endoplasmic reticulum-ass... ( 7) Ecdysone receptor ( 1) Cholesteryl ester transfe... ( 2) Huntingtin ( 77) Lethal(3)malignant brain ... ( 10) 15-hydroxyprostaglandin d... ( 10) Short transient receptor ... ( 19) Transcriptional regulator... ( 5) Aldehyde dehydrogenase di... ( 1) ATP-dependent Clp proteas... ( 111) Thioredoxin glutathione r... ( 24) Cellular tumor antigen p5... ( 560) Cannabinoid CB1 receptor ( 8) ATP-binding cassette sub-... ( 1) Aldehyde dehydrogenase 1A... ( 58) TGF-beta receptor type II ( 2) Histone acetyltransferase... ( 25) Glucagon-like peptide 1 r... ( 213) Glycoprotein hormones alp... ( 110) Tyrosine-protein kinase r... ( 1) Survival motor neuron pro... ( 73) Histone-lysine N-methyltr... ( 68) Microtubule-associated pr... ( 613) Prelamin-A/C ( 542) Lysosomal alpha-glucosida... ( 42) Geminin ( 246) Arachidonate 15-lipoxygen... ( 5) Epoxide hydratase ( 3) Beta-2 adrenergic recepto... ( 6) Inositol monophosphatase ... ( 111) Thyroid hormone receptor ... ( 314) Thyroid stimulating hormo... ( 50) Dihydrofolate reductase ( 1) G protein-coupled recepto... ( 4) Beta-lactamase AmpC ( 613) Ataxin-2 ( 215) Hypoxia-inducible factor ... ( 4) Nuclear factor erythroid ... ( 389) Cruzipain ( 33) Guanine nucleotide-bindin... ( 164) Serine-protein kinase ATM ( 2) Pyruvate kinase isozymes ... ( 2) Nuclear receptor ROR-gamm... ( 140) ATPase family AAA domain-... ( 113) C-X-C chemokine receptor ... ( 3)