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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

Small Molecule Inhibitors

Small molecule inhibitors can bind to target proteins and reduce their biological activity and are often used as tools in biological and pharmacological research. Small molecule inhibitors have many advantages. For example, they can be easily manipulated and can be applied to a variety of cell or animal experiments; they have good permeability to cross cell membranes easily; they have higher stability, which can reduce the instability in an experiment. Small molecule inhibitors have become important tool drugs in life science research in recent years due to their significant advantages in the regulation of different cellular processes, ranging from cell cycle control and mitosis to signaling pathways and gene expression; and from migration and wound healing, to apoptosis and autophagy. Targetmol can provide a variety of small molecule inhibitors of hot signaling pathways for research and development.

Signaling Pathways

  Angiogenesis   Apoptosis   Autophagy   Cell Cycle/Checkpoint   Chromatin/Epigenetic   Cytoskeletal Signaling   DNA Damage/DNA Repair   Endocrinology/Hormones   GPCR/G Protein   Immunology/Inflammation   JAK/STAT signaling   MAPK   Membrane transporter/Ion channel   Metabolism   Microbiology/Virology   Neuroscience   NF-Κb   oxidation-reduction   PI3K/Akt/mTOR signaling   Proteases/Proteasome   Stem Cells   Tyrosine Kinase/Adaptors   Ubiquitination   PROTAC   Others

Angiogenesis

EGFR (236) Syk (34) JAK (150) FLT (111) VDA (2) HER (57) FGFR (94) BTK (67) Bcr-Abl (71) ALK (70) VEGFR (200) FAK (41) PDGFR (108) HIF (62) Src (113)

Apoptosis

Caspase (166) p53 (70) Necroptosis (3) ASK (9) Apoptosis (1268) TNF (245) RIP kinase (32) Mdm2 (33) IAP (22) PD-1/PD-L1 (28) c-RET (42) BCL (153) OXPHOS (5) FOXO1 (2) DAPK (5) Pyroptosis (5) Fas/FasL (3) FKBP (0) Survivin (6) Ferroptosis (108) PERK (25)

Autophagy

Autophagy (931) LRRK2 (21) CXCR (57) lysosomal autophagy (2) Mitophagy (62) FKBP (1)

Cell Cycle/Checkpoint

PD-1/PD-L1 (28) PLK (32) ROCK (55) Rho (28) KSP (4) DHFR (22) IRE1 (17) DUB (55) Wee1 (8) Chk (36) Aurora Kinase (68) c-Myc (27) DYRK (22) Haspin Kinase (3) BMI-1 (6) LIM Kinase (8) Antifolate (19) cell cycle arrest (5) APC (8) Serine/threonin kinase (44) Nucleoside Antimetabolite... (91) DNA/RNA Synthesis (306) CDK (289)

Chromatin/Epigenetic

Histone Demethylase (65) HIF/HIF Prolyl-Hydroxylas... (58) PARP (116) Pim (27) Histone Methyltransferase (155) Epigenetic Reader Domain (214) Sirtuin (74) HIF (62) JAK (150) DNA Methyltransferase (32) Aurora Kinase (68) Histone Acetyltransferase (34) AMPK (109) HDAC (142) PKC (133) Methionine Adenosyltransf... (8) PAD (9)

Cytoskeletal Signaling

Dynamin (9) Integrin (63) HSP (91) PKC (133) Gap Junction Protein (12) Microtubule Associated (156) Myosin (16) Akt (172) Bcr-Abl (71) ROCK (55) FAK (41) Wnt/beta-catenin (126) Arp2/3 Complex (1) PAK (19) Kinesin (33)

DNA Damage/DNA Repair

Topoisomerase (141) DNA Alkylation (25) Telomerase (18) DNA-PK (40) BMI-1 (6) DNA/RNA Synthesis (306) HDAC (142) DNA (24) PARP (116) CRISPR/Cas9 (7) DNA gyrase (16) Nucleoside Antimetabolite... (91) DNA Alkylator/Crosslinker (33) MTH1 (6) DHFR (22) PPAR (177) Sirtuin (74) ATM/ATR (33) DUB (55)

Endocrinology/Hormones

Oxytocin Receptor (8) Estrogen/progestogen Rece... (130) Androgen Receptor (97) Thyroid hormone receptor(... (33) GPR (130) Estrogen Receptor/ERR (115) Glucocorticoid Receptor (84) RAAS (115) Opioid Receptor (135) Aromatase (24) Reductase (40) LHRH (2)

GPCR/G Protein

Melanocortin Receptor (25) Prostaglandin Receptor (165) Histamine Receptor (216) Adenosine Receptor (100) Neuropeptide Y Receptor (40) Melatonin Receptor (10) Bombesin Receptor (11) LPL Receptor (39) GHSR (18) Amylin Receptor (3) GPCR19 (14) Endothelin Receptor (26) TSH Receptor (5) Protease-activated Recept... (34) Hedgehog/Smoothened (36) Neurokinin receptor (54) OX Receptor (23) Glucagon Receptor (49) PAFR (36) Neuropeptide W (1) CGRP Receptor (12) GTPase (15) LPA Receptor (20) Neurotensin Receptor (17) CXCR (57) CaSR (15) Adrenergic Receptor (324) Ras (97) 5-HT Receptor (489) CRFR (15) Adiponectin receptor (4) Apelin receptor (10) Motilin Receptor (2) P2Y Receptor (21) GPR (130) Somatostatin (16) Sigma receptor (38) EBI2/GPR183 (3) Cannabinoid Receptor (80) Guanylate cyclase (21) Bradykinin Receptor (22) cAMP (38) Leukotriene Receptor (18) Dopamine Receptor (290) Oxytocin Receptor (8) Vasopressin Receptor (21) Annexin A (7) GNRH Receptor (23) cholecystokinin (22) SGLT (31) S1P Receptor (45) GRK (11) Melanin-concentrating Hor... (10) Opioid Receptor (135)

Immunology/Inflammation

TLR (84) NO Synthase (105) Thrombopoietin Receptor (4) CD73 (4) Reactive Oxygen Species (191) Cell wall (7) Pyroptosis (5) cGAS (5) IFNAR (11) MALT (6) gp120/CD4 (7) Arginase (8) NOS (114) Histamine Receptor (216) Galectin (5) Cytokine release (0) IL Receptor (199) Complement System (29) Aryl Hydrocarbon Receptor (26) AIM2 (3) CD38 (4) Immunology/Inflammation r... (50) COX (375) MRP (26) LTR (34) PGE Synthase (15) Nrf2 (76) NOD-like Receptor (NLR) (18) CXCR (57) STING (23) NADPH-oxidase (37) Antiviral (80) AhR (22) NOD (30) ROS (128) IRAK (21) MyD88 (7) CCR (67) FLAP (6) PD-1/PD-L1 (28) FKBP (0) Interleukin (50) Prostaglandin Receptor (165)

JAK/STAT signaling

Pim (27) HER (57) STAT (123) JAK (150) EGFR (236)

MAPK

S6 Kinase (37) TOPK (7) Ras (97) ERK (173) MNK (8) Raf (93) KLF (3) MAPK (82) p38 MAPK (161) JNK (102) MLK (11) MEK (65)

Membrane transporter/Ion channel

Proton pump (38) Chloride channel (34) CRM1 (8) Aquaporin (6) Calcium Channel (291) ABC (20) BCRP (12) Sodium Channel (186) VDAC (6) Monoamine Transporter (14) Na-K-Cl cotransporter (5) Anion Exchanger (1) NPC1L1 (7) Potassium Channel (245) iGluR (98) OCT (8) ATPase (98) P-gp (69) OAT (7) Monocarboxylate transport... (11) Na+/Ca2+ Exchanger (8) CFTR (26) Piezo Channel (3) GABA Receptor (200) TRP/TRPV Channel (142) HCN Channel (3) P2X Receptor (45)

Metabolism

Phosphorylase (12) GSNOR (2) Reductase (40) Acyltransferase (29) Transferase (57) NAMPT (13) Fatty Acid Synthase (44) Glucosidase (35) LDL (23) Glucokinase (36) N-Acetylglucosaminyltrans... (1) Drug Metabolite (61) ROR (33) hCE (2) Angiotensin-converting En... (6) Mitochondrial Metabolism (66) Phosphatase (132) DHFR (22) Procollagen C Proteinase (1) Glutathione Peroxidase (24) PDE (213) NUDIX hydrolase (2) FXR (29) Reactive Oxygen Species (191) Carbonic Anhydrase (50) Thioredoxin (1) AhR (22) HIF/HIF Prolyl-Hydroxylas... (58) HSP (91) Amino Acids and Derivativ... (40) Hydrogenase (1) Stearoyl-CoA Desaturase (... (12) Aminopeptidase (15) UGT (11) MAGL (6) P450 (224) Liver X Receptor (22) ATP Citrate Lyase (9) Lipase (24) HMG-CoA Reductase (27) Decarboxylase (6) PKM (10) Transaminase (3) PPAR (177) Acetyl-CoA Carboxylase (11) Lipid (18) Xanthine Oxidase (24) Indoleamine 2,3-Dioxygena... (24) Taste receptor (2) transporter (41) NEDD8 (4) Retinoid Receptor (50) IDO (22) PAI-1 (12) Prolyl Endopeptidase (PR... (2) Phospholipase (81) Isocitrate Dehydrogenase ... (11) NADPH (33) Endogenous Metabolite (1239) RAR/RXR  (5) Dehydrogenase (182) Neprilysin (9) Calcium Channel (291) Amylase (7) Casein Kinase (50) FABP (4) glycosidase (1) Hexokinase (3) SGK (10) Serine/threonin kinase (44) Factor Xa (24) stilbene oxidase (1) MAO (88) FAAH (33) aconitase (1) Lipoxygenase (84) CPT (2) CETP (16) Hydroxylase (24) Adenosine deaminase (6) Epoxide Hydrolase (22)

Microbiology/Virology

Integrase (5) Reverse Transcriptase (45) RSV (17) Antibiotic (621) SARS-CoV (101) Influenza Virus (166) HIV Protease (303) Antifungal (334) GluCls (3) ribosome (36) HBV (84) Virus Protease (84) Parasite (319) CCR (67) HSV (83) Antifection (416) Anti-infection (67) Antibacterial (1076) HCV Protease (123)

Neuroscience

COX (375) AChR (411) NMU2R (1) P-gp (69) OX Receptor (23) AChE (112) Huntingtin (0) NMDAR (96) Norepinephrine (44) Beta-Secretase (17) Neuropeptide W (1) iGluR (98) Melanocortin Receptor (25) 5-HT Receptor (489) Gamma-secretase (46) Histamine Receptor (216) GlyT (12) BACE (35) Monoamine Oxidase (49) Neurokinin receptor (54) Adrenergic Receptor (324) FAAH (33) Dopamine Receptor (290) GluR (159) GABA Receptor (200) MT Receptor (9) CGRP Receptor (12) AAK1 (AP2 associated kina... (6) Serotonin Transporter (43) MAO (88) Neuropeptide Y Receptor (40) P2Y Receptor (21) Opioid Receptor (135) CaMK (44) Adenylyl cyclase (9) Beta Amyloid (93) Adenosine Receptor (100) P2X Receptor (45) Imidazoline Receptor (10)

NF-Κb

IκB/IKK (73) Reactive Oxygen Species (191) NF-κB (382) RANKL/RANK (6) IRAK (21) NOD (30) RIP kinase (32)

oxidation-reduction

Free radical scavengers (13) GST (11) Antioxidant (189) CAT (9) Glutathione reductase (4) GPX (7)

PI3K/Akt/mTOR signaling

PI3K (266) DNA-PK (40) PTEN (9) Akt (172) PI4K (17) S6 Kinase (37) mTOR (127) ATM/ATR (33) GSK-3 (99) PDK (24) AMPK (109) SIK (7) MELK (8)

Proteases/Proteasome

Protease (2) Proteasome (81) Caspase (166) DPP-4 (27) Prolyl Endopeptidase (PR... (2) HCV Protease (123) Carboxypeptidase (7) Thrombin (38) Tyrosinase (99) Glutaminase (8) MMP (125) HIV Protease (303) Gamma-secretase (46) Cysteine Protease (49) Serine Protease (46)

Stem Cells

STAT (123) ROCK (55) Porcupine (8) YAP (16) Casein Kinase (50) GSK-3 (99) Stemness kinase (1) Hippo pathway (5) Wnt/beta-catenin (126) TGF-beta/Smad (69) Smo (22) Gamma-secretase (46) JAK (150) Hedgehog/Smoothened (36)

Tyrosine Kinase/Adaptors

Src (113) PDGFR (108) TAM Receptor (42) c-Fms (34) PYK2 (6) Syk (34) FAK (41) PKA (62) CSF-1R (16) ALK (70) Tie-2 (7) ROS Kinase (13) ACK (5) DYRK (22) Discoidin Domain Receptor... (12) FGFR (94) EGFR (236) FLT (111) Bcr-Abl (71) Hck (4) BTK (67) HER (57) Ephrin Receptor (15) c-Met/HGFR (83) VEGFR (200) c-RET (42) IGF-1R (51) Trk receptor (43) c-Kit (83) Tyrosine Kinases (56)

Ubiquitination

p97 (9) E1/E2/E3 Enzyme (53) DUB (55) Proteasome (81)

PROTAC

PROTAC Linker (171) ATTECs (2) Molecular Glues (9) LYTACs (1) Target Protein Ligand-Lin... (0) SNIPERs (0) Ligands for Target Protei... (11) PROTACs (15) E3 Ligase Ligand-Linker C... (25) AUTACs (1) Ligand for E3 Ligase (67)

Others

Decarboxylase (6) Progesterone Receptor (30) Platelet aggregation (25) CYP19A1 (1) Others (15607) Fer/FerT kinase (1) advanced glycation end pr... (4) DprE1 (5)
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