Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 143.00 | |
5 mg | 35 days | $ 583.00 | |
10 mg | 35 days | $ 1,090.00 |
Description | CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer. |
Molecular Weight | 385.84 |
Formula | C24H16ClNO2 |
CAS No. | 2375613-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF:PBS (pH 7.2) (1:2): 0.3 mg/mL
Ethanol: 12 mg/mL
DMF: 20 mg/mL
DMSO: 5 mg/mL
You can also refer to dose conversion for different animals. More
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CAY10744 2375613-31-1 CAY-10744 CAY 10744 inhibitor inhibit