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Glabranine (Synonyms: Glabranin)

Name: Glabranine
Brand: TargetMol
SKU: TN1689
Price: 289 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TN1689 Copy Product Info

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Glabranine is a natural prenylated flavonoid isolated from Tephrosia species that exhibits potent inhibitory activity against the Dengue virus (DENV) in vitro. Its primary mechanism involves interacting with the soluble ectodomain of the DENV type 2 (DENV2) Envelope (E protein), potentially blocking viral entry or membrane fusion. The presence of the prenyl group is considered essential for its biological potency, making it a valuable scaffold for flavivirus-targeted drug discovery.

Glabranine

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Catalog No. TN1689

Synonyms Glabranin

Cas No. 41983-91-9

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$289	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Glabranine is a natural prenylated flavonoid isolated from Tephrosia species that exhibits potent inhibitory activity against the Dengue virus (DENV) in vitro. Its primary mechanism involves interacting with the soluble ectodomain of the DENV type 2 (DENV2) Envelope (E protein), potentially blocking viral entry or membrane fusion. The presence of the prenyl group is considered essential for its biological potency, making it a valuable scaffold for flavivirus-targeted drug discovery.
In vitro	The ethyl acetate and methanol bark extracts of Melicope glabra were evaluated for their antioxidant capacities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and β-carotene bleaching/linoleic acid system. Both extracts exhibited strong inhibition against the DPPH radical (IC50 values of 24.81 and 13.01 μg ml(-1), respectively) and strong antioxidant activity in β-carotene bleaching assay. Both samples were found to have high phenolic content with values of 39 and 44 mg GAE/g as indicated by Follin-Ciocalteau's reagent. Antioxidant TLC assay-guided isolation on the methanol extract led to the isolation of a new pyranocoumarin, Glabranin (1), umbelliferone (2), scopoletin (3) and sesamin (4), and their structures were determined by spectroscopy[1]
Synonyms	Glabranin

Chemical Properties

Molecular Weight	324.37
Formula	C₂₀H₂₀O₄
Cas No.	41983-91-9
Smiles	O=C1C=2C(=C(CC=C(C)C)C(O)=CC2O)O[C@@H](C1)C3=CC=CC=C3
Relative Density.	1.244 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (246.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0829 mL	15.4145 mL	30.8290 mL	154.1450 mL
5 mM	0.6166 mL	3.0829 mL	6.1658 mL	30.8290 mL
10 mM	0.3083 mL	1.5414 mL	3.0829 mL	15.4145 mL
20 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7072 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	3.0829 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc