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Nrf2/HO-1 activator 1

Catalog No. T61205 CAS 2883506-60-1

Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustrating its potential in therapeutic applications [1].

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Nrf2/HO-1 activator 1 Chemical Structure

Nrf2/HO-1 activator 1, CAS 2883506-60-1

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustrating its potential in therapeutic applications [1].
In vitro	Nrf2/HO-1 activator 1 demonstrates significant neuroprotective effects at concentrations ranging from 0.3 to 30 μM over 24 hours in cell death models induced by 6-OHDA and rotenone. Additionally, at concentrations of 1 to 30 μM over 6 hours, it effectively enhances HO-1 expression in PC12 cells. Furthermore, at a fixed concentration of 12 μM across varying durations from 1 to 12 hours, it actively promotes the phosphorylation of ERK1/2, JNK, and Akt in PC12 cells. In cell viability assays using PC12 cells treated for 4 hours, it showcases its capability to inhibit 6-OHDA-induced toxicity with an IC50 of 3.9 μM and rotenone-induced toxicity with an IC50 of 4.8 μM. Western blot analysis corroborates these findings, revealing dose-dependent inductions in HO-1 expression, most notably achieving a 2-fold increase at 30 μM, and the phosphorylation of ERK1/2, JNK, and Akt, further confirming its neuroprotective mechanisms [1].
In vivo	Nrf2/HO-1 activator 1 reduces lipid peroxide production by 50.5% at a concentration of 100 μM in rat brain homogenates [1].

Molecular Weight	350.36
Formula	C21H18O5
CAS No.	2883506-60-1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Nrf2/HO-1 activator 1 2883506-60-1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.