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DT-061

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Catalog No. T10060LCas No. 1809427-19-7

DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.

DT-061
Other Forms of DT-061:
(1S,2S,3R)-DT-061T100601809427-20-0
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DT-061

😃Good
Catalog No. T10060LCas No. 1809427-19-7
DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,2308-10 weeks8-10 weeks
50 mg$1,6108-10 weeks8-10 weeks
100 mg$2,4408-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction

Bioactivity
Description
DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
In vivo
DT-061 combined with AZD6244 is more significantly efficient. DT-061 (5 mg/kg, oral gavage, 4 weeks) displays single-agent activity in inhibiting H358 or H441 xenograft growth.
Chemical Properties
Molecular Weight520.52
FormulaC25H23F3N2O5S
Cas No.1809427-19-7
Relative Density.1.51 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (240.14 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9212 mL9.6058 mL19.2116 mL96.0578 mL
5 mM0.3842 mL1.9212 mL3.8423 mL19.2116 mL
10 mM0.1921 mL0.9606 mL1.9212 mL9.6058 mL
20 mM0.0961 mL0.4803 mL0.9606 mL4.8029 mL
50 mM0.0384 mL0.1921 mL0.3842 mL1.9212 mL
100 mM0.0192 mL0.0961 mL0.1921 mL0.9606 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PP2ADT-061DT061DT 061
Related Tags: buy DT-061 | purchase DT-061 | DT-061 cost | order DT-061 | DT-061 chemical structure | DT-061 in vivo | DT-061 formula | DT-061 molecular weight
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