Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | (R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.. |
In vitro | The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of (R)-Fadrozole[1]. |
In vivo | Administration of (R)-fadrozole and (S)-fadrozole (0.24 and 1.2 mg/kg; daily; oral) consistently lowers plasma aldosterone levels. However, a reduction in the urinary aldosterone excretion rate was solely observed with (S)-fadrozole. Notably, (R)-fadrozole at the same dosages was effective in reducing preexisting left ventricular interstitial fibrosis by 50%, contrasting with canrenoate's 42% reduction. Unlike its isomer, (S)-fadrozole exhibited no antifibrotic effects. This study utilized SHHF rats, implementing a dosage regimen of 0.24 and 1.2 mg/kg administered orally on a daily basis, which led to decreased plasma aldosterone levels and a significant reversal of left ventricular interstitial fibrosis. |
Synonyms | FAD286, (R)-CGS 16949A free base, (R)-Fadrozole |
Molecular Weight | 223.27 |
Formula | C14H13N3 |
CAS No. | 102676-87-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(R)-Fadrozole 102676-87-9 FAD 286 FAD-286 CGS 16949A free base (R) Fadrozole FAD286 (R)-CGS 16949A free base CGS 16949A (R)Fadrozole Fadrozole inhibitor inhibit