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123B9

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Catalog No. TP2771Cas No. 2225868-19-7

123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.

123B9

123B9

😃Good
Catalog No. TP2771Cas No. 2225868-19-7
123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.
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Product Introduction

Bioactivity
Description
123B9 is a tumor-homing agent characterized as a potent and selective agonist for EphA2 with a dissociation constant (Kd) of 4.0 μM. It specifically targets the ligand-binding domain of the EphA2 tyrosine kinase receptor. Notably, 123B9 does not significantly inhibit the ligand-binding domains of closely related receptors EphA3 and EphA4.
In vivo
Following intravenous administration of 123B9 at a dosage of 30 mg/kg in mice, the compound was detectable in the plasma over time at each tested interval (30 minutes, 1 hour, 2 hours, 4 hours). Plasma concentrations of the compound averaged 447 ng/mL and 569 ng/mL at the 2-hour and 4-hour marks, respectively.
Chemical Properties
Molecular Weight1321.79
FormulaC58H82ClFN12O20
Cas No.2225868-19-7
SmilesC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC(COC2=CC(Cl)=C(F)C=C2)=O)CO)=O)C)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CCO)=O)CCCC)=O)CCC4)[C@@H](C)C)=O)CO)=O)CC(O)=O)=O)CCC3
Sequence{2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-NH2
Sequence Short{2-(3-chloro-4-fluorophenoxy)acetic acid}-SAYPDSVP-{Nle}-{Hsr}-S-NH2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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