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EP3 antagonist 3

Name: EP3 antagonist 3
Brand: TargetMol
SKU: T61357
Rating: 4.5 (1 reviews)

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Catalog No. T61357Cas No. 1227827-88-4

EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).

EP3 antagonist 3

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Catalog No. T61357Cas No. 1227827-88-4

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$954	6-8 weeks	6-8 weeks
50 mg	$1,240	6-8 weeks	6-8 weeks
100 mg	$1,990	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).
Targets&IC50	EP3:8.3 (pKi)

Chemical Properties

Molecular Weight	362.38
Formula	C₂₁H₁₈N₂O₄
Cas No.	1227827-88-4
Smiles	O=C1OC(C(=O)N1)(C2=CC=C(NC2=O)C=3C=CC=4C=CC=CC4C3)C(C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (551.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7595 mL	13.7977 mL	27.5953 mL	137.9767 mL
5 mM	0.5519 mL	2.7595 mL	5.5191 mL	27.5953 mL
10 mM	0.2760 mL	1.3798 mL	2.7595 mL	13.7977 mL
20 mM	0.1380 mL	0.6899 mL	1.3798 mL	6.8988 mL
50 mM	0.0552 mL	0.2760 mL	0.5519 mL	2.7595 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

EP3 antagonist 3

EP3 antagonist 3

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