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EP3 antagonist 3

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Catalog No. T61357Cas No. 1227827-88-4

EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).

EP3 antagonist 3

EP3 antagonist 3

😃Good
Catalog No. T61357Cas No. 1227827-88-4
EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$9546-8 weeks6-8 weeks
50 mg$1,2406-8 weeks6-8 weeks
100 mg$1,9906-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).
Targets&IC50
EP3:8.3 (pKi)
Chemical Properties
Molecular Weight362.38
FormulaC21H18N2O4
Cas No.1227827-88-4
SmilesO=C1OC(C(=O)N1)(C2=CC=C(NC2=O)C=3C=CC=4C=CC=CC4C3)C(C)C
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (551.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7595 mL13.7977 mL27.5953 mL137.9767 mL
5 mM0.5519 mL2.7595 mL5.5191 mL27.5953 mL
10 mM0.2760 mL1.3798 mL2.7595 mL13.7977 mL
20 mM0.1380 mL0.6899 mL1.3798 mL6.8988 mL
50 mM0.0552 mL0.2760 mL0.5519 mL2.7595 mL
100 mM0.0276 mL0.1380 mL0.2760 mL1.3798 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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