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EP3 antagonist 3

Name: EP3 antagonist 3
Brand: TargetMol
SKU: T61357
Rating: 4.5 (1 reviews)

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Catalog No. T61357Cas No. 1227827-88-4

EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).

EP3 antagonist 3

😃Good

Catalog No. T61357Cas No. 1227827-88-4

Pack Size	Price	Availability
25 mg	$954	6-8 weeks
50 mg	$1,240	6-8 weeks
100 mg	$1,990	6-8 weeks

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Product Introduction

Bioactivity

Description	EP3 antagonist 3, a potent and selective EP3 antagonist with the advantage of oral activity, significantly inhibited GR63799- or acetic acid-induced reduction in bladder capacity and PGE2-induced overactive bladder model in spontaneously hypertensive rats (SHR).
Targets&IC50	EP3:8.3 (pKi)

Chemical Properties

Molecular Weight	362.38
Formula	C₂₁H₁₈N₂O₄
Cas No.	1227827-88-4
Smiles	O=C1OC(C(=O)N1)(C2=CC=C(NC2=O)C=3C=CC=4C=CC=CC4C3)C(C)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (551.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7595 mL	13.7977 mL	27.5953 mL	137.9767 mL
5 mM	0.5519 mL	2.7595 mL	5.5191 mL	27.5953 mL
10 mM	0.2760 mL	1.3798 mL	2.7595 mL	13.7977 mL
20 mM	0.1380 mL	0.6899 mL	1.3798 mL	6.8988 mL
50 mM	0.0552 mL	0.2760 mL	0.5519 mL	2.7595 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3798 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc