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TCO-PEG3-Biotin

Name: TCO-PEG3-Biotin
Brand: TargetMol
SKU: T18766
Price: 86 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18766

TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.

TCO-PEG3-Biotin

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Catalog No. T18766

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$86	-	In Stock
5 mg	$208	-	In Stock
10 mg	$338	-	In Stock
25 mg	$565	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.
In vitro	Antibody-drug conjugates (ADCs) consist of an antibody linked to a cytotoxin via an ADC linker[1].

Chemical Properties

Molecular Weight	570.74
Formula	C₂₇H₄₆N₄O₇S
Smiles	O=C(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)O[C@H]3CCC/C([H])=C/CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (175.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7521 mL	8.7606 mL	17.5211 mL	87.6056 mL
5 mM	0.3504 mL	1.7521 mL	3.5042 mL	17.5211 mL
10 mM	0.1752 mL	0.8761 mL	1.7521 mL	8.7606 mL
20 mM	0.0876 mL	0.4380 mL	0.8761 mL	4.3803 mL
50 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7521 mL
100 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.8761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc