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TCO-PEG3-Biotin

Name: TCO-PEG3-Biotin
Brand: TargetMol
SKU: T18766
Price: 86 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18766

TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.

TCO-PEG3-Biotin

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Catalog No. T18766

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$86	-	In Stock
5 mg	$208	-	In Stock
10 mg	$338	-	In Stock
25 mg	$565	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	TCO-PEG3-Biotin is a PEG-based cleavable ADC linker for synthesising antibody-drug conjugates (ADCs). Its TCO moiety undergoes click chemistry iEDDA reactions with molecules containing tetrazine groups.
In vitro	Antibody-drug conjugates (ADCs) consist of an antibody linked to a cytotoxin via an ADC linker[1].

Chemical Properties

Molecular Weight	570.74
Formula	C₂₇H₄₆N₄O₇S
Smiles	O=C(NCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)O[C@H]3CCC/C([H])=C/CC3
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (175.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7521 mL	8.7606 mL	17.5211 mL	87.6056 mL
5 mM	0.3504 mL	1.7521 mL	3.5042 mL	17.5211 mL
10 mM	0.1752 mL	0.8761 mL	1.7521 mL	8.7606 mL
20 mM	0.0876 mL	0.4380 mL	0.8761 mL	4.3803 mL
50 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7521 mL
100 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.8761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc