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BCI-137

Name: BCI-137
Brand: TargetMol
SKU: T23777
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23777Cas No. 112170-24-8

Alias BCI137

BCI-137 is an Argonaute 2 ligand. It acts by targeting the MicroRNA binding domain.

BCI-137

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Purity: 99.72%

Catalog No. T23777Alias BCI137Cas No. 112170-24-8

BCI-137 is an Argonaute 2 ligand. It acts by targeting the MicroRNA binding domain.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$127	In Stock	In Stock
25 mg	$218	In Stock	In Stock
50 mg	$323	In Stock	In Stock
100 mg	$483	In Stock	In Stock
200 mg	$689	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.72%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

BCI-137 AI Summary

BCI-137 shows bioactivity in multiple assays, acting as an inhibitor with notable potencies. In an assay targeting inhibitors of Polymerase Iota, the compound exhibited a potency of 89,125.1 nM. Additionally, in a primary assay for delayed death inhibitors of the malarial parasite plastid, BCI-137 displayed a potency of 9,285.0 nM. Furthermore, it demonstrates a binding affinity to AGO2, as evidenced by a RIP assay, with a dissociation constant (Kd) of 126,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BCI-137 is an Argonaute 2 ligand. It acts by targeting the MicroRNA binding domain.
Synonyms	BCI137

Chemical Properties

Molecular Weight	313.29
Formula	C₁₁H₁₁N₃O₆S
Cas No.	112170-24-8
Smiles	S(NC(C(O)=O)C)(=O)(=O)C=1C=C2C(=CC1)NC(=O)C(=O)N2
Relative Density.	1.566 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (446.87 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.38 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1919 mL	15.9597 mL	31.9193 mL	159.5965 mL
5 mM	0.6384 mL	3.1919 mL	6.3839 mL	31.9193 mL
10 mM	0.3192 mL	1.5960 mL	3.1919 mL	15.9597 mL
20 mM	0.1596 mL	0.7980 mL	1.5960 mL	7.9798 mL
50 mM	0.0638 mL	0.3192 mL	0.6384 mL	3.1919 mL
100 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5960 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc