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2-(Phosphonooxy)benzoic acid

Name: 2-(Phosphonooxy)benzoic acid
Brand: TargetMol
SKU: T1427
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1427Cas No. 6064-83-1

Alias Salicyl phosphate, Fosfosal, Disdolen, 2-phosphonoxy benzoic acid

2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.

2-(Phosphonooxy)benzoic acid

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Purity: 97.19%

Catalog No. T1427Alias Salicyl phosphate, Fosfosal, Disdolen, 2-phosphonoxy benzoic acidCas No. 6064-83-1

2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$51	-	In Stock
10 mg	$89	-	In Stock
25 mg	$189	-	In Stock
50 mg	$297	-	In Stock
100 mg	$447	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.19%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

2-(Phosphonooxy)benzoic acid AI Summary

2-(Phosphonooxy)benzoic acid exhibits diverse bioactivities and antiviral properties. It shows significant binding affinity towards the phosphotyrosine binding pocket of the Src protein tyrosine kinase SH2 domain with an IC50 value of 2,000,000.0 nM. The compound demonstrates inhibitory activity against a range of targets including HSD17B4, JMJD2E, ALDH1A1, Ubiquitin-specific Protease USP2a, HPGD, and the malarial parasite plastid, with potency values between 3981.1 nM and 4256.2 nM. It has also shown potential in blocking Ebola Virus entry with AC50 values from 1.995 µM to 8.913 µM, and moderate activity in cell viability assays with an IC50 of 20,000.0 nM across various cell lines. Furthermore, 2-(Phosphonooxy)benzoic acid demonstrates inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, suggesting activity against these transporters. It also exhibits low-level inhibition of SARS-CoV-2 replication in Vero E6 cells and antiviral activity in HRCE cells against the USA-WA1/2020 strain, with a hit score of 0.1484. However, its antiviral IC50 values exceed 20,000.0 nM in different assays, indicating limited potency. Additionally, the compound shows toxicity in rats with a pLD50 of 7.01, and has no significant bioactivity in various in vitro receptor and enzyme assays, with AC50 values greater than 30,000.0 nM, suggesting weak binding affinity. Overall, 2-(Phosphonooxy)benzoic acid has multifaceted bioactivities and potential as a multifunctional compound in various biological contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.
Synonyms	Salicyl phosphate, Fosfosal, Disdolen, 2-phosphonoxy benzoic acid

Chemical Properties

Molecular Weight	218.1
Formula	C₇H₇O₆P
Cas No.	6064-83-1
Smiles	OC(=O)c1ccccc1OP(O)(O)=O
Relative Density.	1.695 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (275.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5851 mL	22.9253 mL	45.8505 mL	229.2526 mL
5 mM	0.9170 mL	4.5851 mL	9.1701 mL	45.8505 mL
10 mM	0.4585 mL	2.2925 mL	4.5851 mL	22.9253 mL
20 mM	0.2293 mL	1.1463 mL	2.2925 mL	11.4626 mL
50 mM	0.0917 mL	0.4585 mL	0.9170 mL	4.5851 mL
100 mM	0.0459 mL	0.2293 mL	0.4585 mL	2.2925 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc