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Malic enzyme inhibitor ME1

Name: Malic enzyme inhibitor ME1
Brand: TargetMol
SKU: T11940
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11940Cas No. 522649-59-8

Alias ME1

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

Malic enzyme inhibitor ME1

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Purity: 99.84%

Catalog No. T11940Alias ME1Cas No. 522649-59-8

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$363	In Stock	In Stock
25 mg	$616	In Stock	In Stock
50 mg	$877	In Stock	In Stock
100 mg	$1,180	-	In Stock
500 mg	$2,390	-	In Stock
1 mL x 10 mM (in DMSO)	$159	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.84%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.
Targets&IC50	Malic enzyme:0.15 μM
In vitro	In HCT116 cells and HT29 cells, Malic enzyme inhibitor ME1 (50 μM) significantly reduces the total number of cells and cell colonies in a dose-dependent manner. In MTS cells, Malic enzyme inhibitor ME1 decreases the viability and metabolic activities of cells[2].
Synonyms	ME1

Chemical Properties

Molecular Weight	351.4
Formula	C₂₀H₂₁N₃O₃
Cas No.	522649-59-8
Smiles	Oc1ccc(cc1)N1CCN(CC1)C1CC(=O)N(C1=O)c1ccccc1
Relative Density.	1.342 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (711.44 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.39 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8458 mL	14.2288 mL	28.4576 mL	142.2880 mL
5 mM	0.5692 mL	2.8458 mL	5.6915 mL	28.4576 mL
10 mM	0.2846 mL	1.4229 mL	2.8458 mL	14.2288 mL
20 mM	0.1423 mL	0.7114 mL	1.4229 mL	7.1144 mL
50 mM	0.0569 mL	0.2846 mL	0.5692 mL	2.8458 mL
100 mM	0.0285 mL	0.1423 mL	0.2846 mL	1.4229 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc