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Lanopepden

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Catalog No. T11815Cas No. 1152107-25-9
Alias GSK-1322322J, GSK-1322322B, GSK 1322322

Lanopepden (GSK 1322322) is a potent peptide deformylase inhibitor effective against Staphylococcus aureus strains ATCC 29213 and ATCC 25923, and is applicable in the study of pneumonia, dermatological, and infectious diseases.

Lanopepden

Lanopepden

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🥰Excellent
Purity: 99.61%
Catalog No. T11815Alias GSK-1322322J, GSK-1322322B, GSK 1322322Cas No. 1152107-25-9
Lanopepden (GSK 1322322) is a potent peptide deformylase inhibitor effective against Staphylococcus aureus strains ATCC 29213 and ATCC 25923, and is applicable in the study of pneumonia, dermatological, and infectious diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$273In StockIn Stock
5 mg$948In StockIn Stock
10 mg$1,270In StockIn Stock
25 mg$1,890In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.61%
ee:100%
Appearance:Solid
Color:White to Yellow
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Product Introduction

Lanopepden AI Summary
Lanopepden exhibits significant antibacterial activity against a range of bacterial strains, including methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, methicillin-sensitive Staphylococcus aureus and Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, and Escherichia coli expressing extended-spectrum beta-lactamase. Its Minimum Inhibitory Concentration (MIC) values vary, with some strains such as methicillin-resistant Staphylococcus epidermidis showing high sensitivity (MIC = 0.015 ug/mL), while others like Enterococcus faecalis exhibit resistance (MIC > 64.0 ug/mL). Moreover, Lanopepden functions as a potent inhibitor against Staphylococcus aureus PDF, Haemophilus influenzae PDF, and Streptococcus pneumoniae PDF with IC50 values of 12.0 nM, 3.0 nM, and 3.0 nM respectively. It also shows antimicrobial activity against Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pneumoniae with MIC values ranging from 0.5 to 2.0 ug/mL. Additionally, Lanopepden has good solubility (241000.0 nM) and high oral bioavailability (91.0% in rats)..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
Lanopepden (GSK 1322322) is a potent peptide deformylase inhibitor effective against Staphylococcus aureus strains ATCC 29213 and ATCC 25923, and is applicable in the study of pneumonia, dermatological, and infectious diseases.
SynonymsGSK-1322322J, GSK-1322322B, GSK 1322322
Chemical Properties
Molecular Weight479.55
FormulaC22H34FN7O4
Cas No.1152107-25-9
SmilesFC=1C(=NC(C)=NC1NNC([C@H](CC2CCCC2)CN(C=O)O)=O)N3C[C@@]4(N(CC3)CCOC4)[H]
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (41.71 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (4.17 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0853 mL10.4264 mL20.8529 mL104.2644 mL
5 mM0.4171 mL2.0853 mL4.1706 mL20.8529 mL
10 mM0.2085 mL1.0426 mL2.0853 mL10.4264 mL
20 mM0.1043 mL0.5213 mL1.0426 mL5.2132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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