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Citicoline

Name: Citicoline
Brand: TargetMol
SKU: T0136
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0136Cas No. 987-78-0

Alias cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-Choline

Citicoline (CDP-Choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.

Citicoline

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Purity: 99.84%

Catalog No. T0136Alias cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-CholineCas No. 987-78-0

Citicoline (CDP-Choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$42	In Stock	In Stock
200 mg	$53	In Stock	In Stock
500 mg	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Color:White

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COA HPLC HNMR

Product Introduction

Citicoline AI Summary

Citicoline is a diverse bioactive molecule with several notable pharmacological activities. It acts as an inhibitor of Pin1, a regulator of G protein signaling 4 (RGS4), and an enhancer of Arylsulfatase A (ASA1), with potency values ranging from 58.0 nM to 30,131.3 nM across different assays. It has demonstrated neuroprotective effects in primary cortical neurons of Sprague-Dawley rats by reversing oxygen-glucose deprivation-induced neuronal damage at concentrations of 10 µM, 100 µM, and 250 µM, showing activity levels between 53.2% and 87.4% relative to the control. Additionally, Citicoline inhibits sodium fluorescein uptake by 69.94% and 81.06% in OATP1B3 and OATP1B1 transfected CHO cells, respectively. In antiviral contexts, the compound exhibited inhibitory activity against SARS-CoV-2 induced cytotoxicity in Caco-2 cells, although the inhibition was minimal at -1.92% at 10 µM after 48 hours. Its SARS-CoV-2 3CL-Pro protease inhibition was 2.2% at 20 µM. In VERO-6 cells, the inhibition of SARS-CoV-2 induced cytotoxicity was -0.07%. Citicoline was also evaluated for its effects on human HDAC6, showing 6.37% inhibition with a commercial peptide substrate, but -5.67% with a custom substrate. Despite binding to various human and rodent receptors, its significance in ligand-binding assays remains low with AC50 values exceeding 30,000.0 nM, indicating weak affinity. Finally, it showed no significant activity predictive of Drug Induced Liver Injury (DILI) according to the DILIps validation dataset, scoring 0.0 in both O'Brien and Pfizer data..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Citicoline (CDP-Choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
Synonyms	cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-Choline

Chemical Properties

Molecular Weight	488.32
Formula	C₁₄H₂₆N₄O₁₁P₂
Cas No.	987-78-0
Smiles	O[C@H]1[C@@H](O[C@H](COP(OP(OCC[N+](C)(C)C)(=O)[O-])(=O)O)[C@H]1O)N2C(=O)N=C(N)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 85 mg/mL (174.07 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0478 mL	10.2392 mL	20.4784 mL	102.3919 mL
5 mM	0.4096 mL	2.0478 mL	4.0957 mL	20.4784 mL
10 mM	0.2048 mL	1.0239 mL	2.0478 mL	10.2392 mL
20 mM	0.1024 mL	0.5120 mL	1.0239 mL	5.1196 mL
50 mM	0.0410 mL	0.2048 mL	0.4096 mL	2.0478 mL
100 mM	0.0205 mL	0.1024 mL	0.2048 mL	1.0239 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc