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BI-2545

Name: BI-2545
Brand: TargetMol
SKU: T14560
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14560Cas No. 2162961-71-7

Alias BI2545, BI 2545

BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, respectively, and reduces plasma LPA levels in rats.

BI-2545

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Purity: 98.85%

Catalog No. T14560Alias BI2545, BI 2545Cas No. 2162961-71-7

BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, respectively, and reduces plasma LPA levels in rats.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$49	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.85%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, respectively, and reduces plasma LPA levels in rats.
Targets&IC50	ATX (human):2.2 nM, ATX (rat):3.4 nM
In vitro	BI-2545, which exhibits single-digit nanomolar activity in enzyme assays (IC50 = 0.9 nM), demonstrates high potency in rat whole blood (IC50 = 4 nM) and possesses a clean hERG profile along with favorable pharmacokinetic properties [1].
In vivo	In the rat PK/PD model, BI-2545 (10 mg/kg, p.o.) demonstrated a significant reduction in LPA levels, decreasing total plasma LPA by up to 90% [1].
Synonyms	BI2545, BI 2545

Chemical Properties

Molecular Weight	527.42
Formula	C₂₃H₁₉F₆N₅O₃
Cas No.	2162961-71-7
Smiles	C(NC(=O)C=1C=C2C(=CC1)N=NN2)[C@@H]3[C@@]4([C@]3(CN(C(OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)C4)[H])[H]
Relative Density.	1.513 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (379.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8960 mL	9.4801 mL	18.9602 mL	94.8011 mL
5 mM	0.3792 mL	1.8960 mL	3.7920 mL	18.9602 mL
10 mM	0.1896 mL	0.9480 mL	1.8960 mL	9.4801 mL
20 mM	0.0948 mL	0.4740 mL	0.9480 mL	4.7401 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8960 mL
100 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.9480 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc