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Sulmazole

Catalog No. T28881   CAS 73384-60-8
Synonyms: Vardax, AR-L 115BS, AR-L 115-BS

Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.

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Sulmazole Chemical Structure
Sulmazole, CAS 73384-60-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 32.00
5 mg In stock $ 72.00
10 mg In stock $ 106.00
25 mg In stock $ 178.00
50 mg In stock $ 266.00
100 mg In stock $ 397.00
500 mg In stock $ 945.00
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Purity: 99.64%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.
In vitro In cell-free biochemical assays, observed activities of sulmazole are cyclic nucleotide phosphodiesterase inhibitors with similar potencies and selectivities for the Type III enzyme (IC50=5.0 +/- 1.9 X 10(-5) M). sulmazole had little or no effects on sarcolemmal Na+/K+-ATPase, Ca2+ ATPase or Na+/Ca2+ exchange, and sulmazole had a small, stimulatory effect on myofibrillar ATPase.[2]
In vivo In anaesthetized guinea pigs and dogs, bolus i.v. injections of sulmazole (0.1-10.0 mg kg-1) caused a significant, dose-related increase in ventricular dP/dt, and a reduction in diastolic blood pressure, with small increases in heart rate.[1]
Synonyms Vardax, AR-L 115BS, AR-L 115-BS
Molecular Weight 287.34
Formula C14H13N3O2S
CAS No. 73384-60-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.25 mg/mL (21.75 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Parsons WJ, et al. The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol Pharmacol. 1988 Apr;33(4):441-8. 2. Allan G, et al. A comparative study of the cardiovascular and biochemical actions of the imidazo [4,5b] pyridine sulmazole and an imidazo [4,5c] pyridine analogue, BW A746C. Br J Pharmacol. 1988 Feb;93(2):387-98. 3. Achenbach C, et al. The response of the calcium dependent myocardial contractility to the new cardiotonic agent sulmazole. Arzneimittelforschung. 1984;34(11):1498-506. 4. McGarry SJ, et al. Activation of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by analogues of sulmazole. Br J Pharmacol. 1994 Apr;111(4):1212-20.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Membrane Protein-targeted Compound Library Inhibitor Library Anti-Parasitic Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Sulmazole 73384-60-8 GPCR/G Protein Metabolism Microbiology/Virology Neuroscience PDE Parasite Adenosine Receptor Vardax AR-L 115BS AR-L 115-BS inhibitor inhibit

 

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