Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 106.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 266.00 | |
100 mg | In stock | $ 397.00 | |
500 mg | In stock | $ 945.00 |
Description | Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulmazole has been shown to improve cardiac index, low pulmonary capillary wedge pressure, and can be used in the study of heart failure.Sulmazole is a small molecule cGMP-PDE inhibitor. |
In vitro | In cell-free biochemical assays, observed activities of sulmazole are cyclic nucleotide phosphodiesterase inhibitors with similar potencies and selectivities for the Type III enzyme (IC50=5.0 +/- 1.9 X 10(-5) M). sulmazole had little or no effects on sarcolemmal Na+/K+-ATPase, Ca2+ ATPase or Na+/Ca2+ exchange, and sulmazole had a small, stimulatory effect on myofibrillar ATPase.[2] |
In vivo | In anaesthetized guinea pigs and dogs, bolus i.v. injections of sulmazole (0.1-10.0 mg kg-1) caused a significant, dose-related increase in ventricular dP/dt, and a reduction in diastolic blood pressure, with small increases in heart rate.[1] |
Synonyms | Vardax, AR-L 115BS, AR-L 115-BS |
Molecular Weight | 287.34 |
Formula | C14H13N3O2S |
CAS No. | 73384-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.25 mg/mL (21.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sulmazole 73384-60-8 GPCR/G Protein Metabolism Microbiology/Virology Neuroscience PDE Parasite Adenosine Receptor Vardax AR-L 115BS AR-L 115-BS inhibitor inhibit