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Olivetol

Name: Olivetol
Brand: TargetMol
SKU: T3736
Rating: 4.5 (1 reviews)

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Catalog No. T3736Cas No. 500-66-3

Alias 5-Pentylresorcinol, 5-n-Amylresorcinol

Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.

Olivetol

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Purity: 99.98%

Catalog No. T3736Alias 5-Pentylresorcinol, 5-n-AmylresorcinolCas No. 500-66-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$49	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:Red

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Olivetol AI Summary

Olivetol has been assessed for its various bioactivities and pharmacological effects. In an assay utilizing tetrahydrocannabinol-seizure susceptible (THC-SS) rabbits, it demonstrated zero relative potency in inducing convulsions; when administered intravenously at 20 mg/kg, none of the four tested rabbits exhibited convulsions. Olivetol shows antibacterial activity against several resistant strains of Staphylococcus aureus, with Minimum Inhibitory Concentrations (MICs) ranging from 64.0 µg/mL to 128.0 µg/mL, depending on the specific bacterial strain and exposure duration. In enzyme studies, Olivetol affects prenyltransferase activity in Streptomyces coelicolor A3(2), influencing the formation of specific benzene-diol products. The Km and Kcat values indicate its substrate affinity and catalytic activity, providing insight into its enzymatic efficiency. Additionally, the compound exhibits diverse bioactivities in multiple assays: - Cell viability assay via intracellular ATP measurement: potency of 19952.6 nM - Cytotoxicity assay with a focus on dead cells: potency of 5011.9 nM - Activator and inhibitor of Cytochrome P450 3A4: potency of 12589.3 nM - Agonist of estrogen receptor alpha signaling: potency of 22387.2 nM - Antagonist of peroxisome proliferator-activated receptor delta signaling: potency of 50118.7 nM - Agonist of the antioxidant response element (ARE) signaling pathway: potency of 42163.2 nM - Disruptor of mitochondrial membrane potential: potencies of 37578.0 nM at 5-hour and 1-hour durations - Antagonist of retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: potency of 26603.2 nM, with a counter screen potency of 74978.0 nM. Lastly, Olivetol moderately inhibits ovine COX-1 with an IC50 of 13630.0 nM and human recombinant COX-2 with an IC50 of 17260.0 nM, showing a slight preference for COX-1 (Ratio IC50 = 0.79). It demonstrates minimal inhibition of human recombinant 5-LOX, achieving less than 50% inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.
Targets&IC50	CYP1A1:13.8 μM, CYP2C19:15.3 μM
Synonyms	5-Pentylresorcinol, 5-n-Amylresorcinol

Chemical Properties

Molecular Weight	180.24
Formula	C₁₁H₁₆O₂
Cas No.	500-66-3
Smiles	CCCCCC1=CC(O)=CC(O)=C1
Relative Density.	1.068 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (249.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5482 mL	27.7408 mL	55.4816 mL	277.4079 mL
5 mM	1.1096 mL	5.5482 mL	11.0963 mL	55.4816 mL
10 mM	0.5548 mL	2.7741 mL	5.5482 mL	27.7408 mL
20 mM	0.2774 mL	1.3870 mL	2.7741 mL	13.8704 mL
50 mM	0.1110 mL	0.5548 mL	1.1096 mL	5.5482 mL
100 mM	0.0555 mL	0.2774 mL	0.5548 mL	2.7741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc